ArticleNucleic acids research1997
Molecular cloning and analysis of Schizosaccharomyces pombe Reb1p: sequence-specific recognition of two sites in the far upstream rDNA intergenic spacer.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Short-Homology-Mediated CRISPR/Cas9-Based Method for Genome Editing in Fission Yeast.G3 (Bethesda, Md.) · 2019Article
- RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes.Genes & development · 2018Article
- Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1-Ter DNA complex.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Mechanism and physiological significance of programmed replication termination.Seminars in cell & developmental biology · 2014Review
- Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Local and global functions of Timeless and Tipin in replication fork protection.Cell cycle (Georgetown, Tex.) · 2012Review
- The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.The EMBO journal · 2012Article
- A putative transcription factor MYT2 regulates perithecium size in the ascomycete Gibberella zeae.PloS one · 2012Article
- "Chromosome kissing" and modulation of replication termination.Bioarchitecture · 2011Article
- Article
- Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe.Molecular and cellular biology · 2008Article
- Article
- Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex.Molecular and cellular biology · 2006Article
- A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation.The EMBO journal · 2006Article
- swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Transcription termination factor reb1p causes two replication fork barriers at its cognate sites in fission yeast ribosomal DNA in vivo.Molecular and cellular biology · 2004Article
- The essential transcription factor Reb1p interacts with the CLB2 UAS outside of the G2/M control region.Nucleic acids research · 2003Article
- Complex mechanism of site-specific DNA replication termination in fission yeast.The EMBO journal · 2003Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coding sequences for a Schizosaccharomyces pombe sequence-specific DNA binding protein, Reb1p, have been cloned. The predicted S. pombe Reb1p is 24-29% identical to mouse TTF-1 (transcription termination factor-1) and Saccharomyces cerevisiae REB1 protein, both of which direct termination of RNA polymerase I catalyzed transcripts. The S.pombe Reb1 cDNA encodes a predicted polypeptide of 504 amino acids with a predicted molecular weight of 58.4 kDa. The S. pombe Reb1p is unusual in that the bipartite DNA binding motif identified originally in S.cerevisiae and Klyveromyces lactis REB1 proteins is uninterrupted and thus S.pombe Reb1p may contain the smallest natural REB1 homologous DNA binding domain. Its genomic coding sequences were shown to be interrupted by two introns. A recombinant histidine-tagged Reb1 protein bearing the rDNA binding domain has two homologous, sequence-specific binding sites in the S. pomber DNA intergenic spacer, located between 289 and 480 nt downstream of the end of the approximately 25S rRNA coding sequences. Each binding site is 13-14 bp downstream of two of the three proposed in vivo termination sites. The core of this 17 bp site, AGGTAAGGGTAATGCAC, is specifically protected by Reb1p in footprinting analysis.
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