ArticleNucleic acids research1997
Mitochondrial tRNAs in the lower fungus Spizellomyces punctatus: tRNA editing and UAG 'stop' codons recognized as leucine.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 107 citations in OpenAlex.
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- Suppression of amber stop codons impairs pathogenicity in Salmonella.FEBS letters · 2025Article
- Multiple independent genetic code reassignments of the UAG stop codon in phyllopharyngean ciliates.PLoS genetics · 2024Article
- Thg1 family 3'-5' RNA polymerases as tools for targeted RNA synthesis.RNA (New York, N.Y.) · 2024Article
- Characterization of the mitogenome of Gongronella sp. w5 reveals substantial variation in Mucoromycota.Applied microbiology and biotechnology · 2022Article
- Fungal Mitogenomes: Relevant Features to Planning Plant Disease Management.Frontiers in microbiology · 2020Review
- Metatranscriptomic reconstruction reveals RNA viruses with the potential to shape carbon cycling in soil.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolution and Unprecedented Variants of the Mitochondrial Genetic Code in a Lineage of Green Algae.Genome biology and evolution · 2019Article
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- The mitochondrial genomes of two walnut pests,PeerJ · 2018Article
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- Genome Sequence of Spizellomyces punctatus.Genome announcements · 2016Article
- In vitro substrate specificities of 3'-5' polymerases correlate with biological outcomes of tRNA 5'-editing reactions.FEBS letters · 2015Article
- Mitochondrial tRNA 5'-editing in Dictyostelium discoideum and Polysphondylium pallidum.The Journal of biological chemistry · 2014Article
- Article
- Strikingly bacteria-like and gene-rich mitochondrial genomes throughout jakobid protists.Genome biology and evolution · 2013Article
- Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily.RNA (New York, N.Y.) · 2012Review
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- Termination of protein synthesis in mammalian mitochondria.The Journal of biological chemistry · 2011Review
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitochondrial DNA of the chytridiomycete fungus Spizellomyces punctatusen codes only eight tRNAs, although a minimal set of 24-25 tRNAs is normally found in fungi. One of these tRNAs has a CAU anticodon and is structurally related to leucine tRNAs, which would permit the translation of the UAG 'stop' codons that occur in most of its protein genes. The predicted structures of all S. punctatus tRNAs have the common feature of containing one to three mis-pairings in the first three positions of their acceptor stems. Such mis-pairing is expected to impair proper folding and processing of tRNAs from their precursors. Five of these eight RNAs were shown to be edited at the RNA level, in the 5'portion of the molecules. These changes include both pyrimidine to purine and A to G substitutions that restore normal pairing in the acceptor stem. Editing was not found at other positions of the tRNAs, or in the mitochondrial mRNAs of S. punctatus. While tRNA editing has not been observed in other fungi, the editing pattern inS.punctatus is virtually identical to that described in the amoeboid protozoan Acanthamoeba castellanii. If this type of mitochondrial tRNA editing has originated from their common ancestor, one has to assume that it was independently lost in plants, animals and in most fungi. Alternatively, editing might have evolved independently, or the genes coding for the components of the editing machinery were laterally transferred.
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