ArticleNucleic acids research1997
Evaluation of pyrimidine PNA binding to ssDNA targets from nonequilibrium melting experiments.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA.Nucleic acids research · 2007Article
- Hybridization of complementary and homologous peptide nucleic acid oligomers to a guanine quadruplex-forming RNA.Biochemistry · 2006Article
- Peptide nucleic acids: versatile tools for gene therapy strategies.Advanced drug delivery reviews · 2000Review
- Inhibition of PNA triplex formation by N4-benzoylated cytosine.Nucleic acids research · 1998Article
- Synthesis and evaluation of some properties of chimeric oligomers containing PNA and phosphono-PNA residues.Nucleic acids research · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slow kinetics of homopyrimidine PNA binding to single stranded DNA and RNA targets is manifested in significant hysteresis in thermal UV absorption experiments. We have compared temperatures of dissociation (Tdis) and reassociation (Tass) for triplexes formed by DNA and single or bis PNAs with K50 derived from gel mobility experiments. Results indicated there was no correlation between Tdis and K50 while reasonable correlation between Tass and K50 was found. This correlation enabled use of easy thermal UV absorption experiments for evaluation of PNA binding to DNA/RNA targets.
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Registered trials
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