ArticleNucleic acids research1997
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 136 citations in OpenAlex.
- The Cap-Independent Translation of Survivin 5'UTR and HIV-1 IRES Sequences Is Inhibited by Oxidative Stress Produced byBiomolecules · 2026Article
- Deep structural clustering reveals hidden systematic biases in RNA sequencing data.Genome research · 2025Article
- Molecular characterization of superoxide dismutase and catalase genes, and the induction of antioxidant genes under the zinc oxide nanoparticle-induced oxidative stress in air-breathing magur catfish (Clarias magur).Fish physiology and biochemistry · 2021Article
- Role of the RNA-binding protein La in cancer pathobiology.RNA biology · 2021Review
- Article
- Article
- A Novel Hypovirus Species From Xylariaceae Fungi Infecting Avocado.Frontiers in microbiology · 2018Article
- More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer.Cellular and molecular life sciences : CMLS · 2017Review
- The alpaca melanocortin 1 receptor: gene mutations, transcripts, and relative levels of expression in ventral skin biopsies.TheScientificWorldJournal · 2015Article
- Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements.RNA biology · 2015Article
- DSPP contains an IRES element responsible for the translation of dentin phosphophoryn.Journal of dental research · 2014Article
- Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.Biochemical and biophysical research communications · 2012Article
- Preference of IRES-mediated initiation of translation during hibernation in golden-mantled ground squirrels, Spermophilus lateralis.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site.The Journal of biological chemistry · 2010Article
- The 5'-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation.Molecular pharmacology · 2010Article
- Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Expansion of the human mu-opioid receptor gene architecture: novel functional variants.Human molecular genetics · 2009Article
- Linkage mapping of putative regulator genes of barley grain development characterized by expression profiling.BMC plant biology · 2009Article
- In silico investigations on functional and haplotype tag SNPs associated with congenital long QT syndromes (LQTSs).Genomic medicine · 2008Article
- Characterization of the internal IRES element of the zebrafish connexin55.5 reveals functional implication of the polypyrimidine tract binding protein.BMC molecular biology · 2008Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 5'-non-translated regions (5'NTR) of human immunoglobulin heavy chain binding protein (BiP), Antennapedia (Antp) ofDrosophilaand human fibroblast growth factor 2 (FGF-2) mRNAs are reported to mediate translation initiation by an internal ribosome binding mechanism. In this study, we investigate predicted features of the higher order structures folded in these 5'NTR sequences. Statistical analyses of RNA folding detected a 92 nt unusual folding region (UFR) from 129 to 220, close to the initiator AUG in the BiP mRNA. Details of the structural analyses show that the UFR forms a Y-type stem-loop structure with an additional stem-loop in the 3'-end resembling the common structure core found in the internal ribosome entry site (IRES) elements of picornavirus. The Y-type structural motif is also conserved among a number of divergent BiP mRNAs. We also find two RNA elements in the 5'-leader sequence of human FGF-2. The first RNA element (96 nt) is 2 nt upstream of the first CUG start codon located in the reported IRES element of human FGF-2. The second (107 nt) is immediately upstream of the authentic initiator AUG of the main open reading frame. Intriguingly, the folded RNA structural motif in the two RNA elements is conserved in other members of FGF family and shares the same structural features as that found in the 5'NTR of divergent BiP mRNAs. We suggest that the common RNA structural motif conserved in the diverse BiP and FGF-2 mRNAs has a general function in the internal ribosome binding mechanism of cellular mRNAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.