ArticleThe Journal of cell biology1997
Dynamic properties of an inositol 1,4,5-trisphosphate- and thapsigargin-insensitive calcium pool in mammalian cell lines.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 77 citations in OpenAlex.
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- FAD-linked Presenilin-1 V97L mutation impede tranport regulation and intracellular Ca(2+) homeostasis under ER stress.International journal of clinical and experimental medicine · 2015Article
- Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions.Journal of cell science · 2010Article
- Peroxisomes as novel players in cell calcium homeostasis.The Journal of biological chemistry · 2008Article
- Divergent calcium signaling in RBCs from Tropidurus torquatus (Squamata--Tropiduridae) strengthen classification in lizard evolution.BMC physiology · 2007Article
- Dynamics of calcium fluxes in nonexcitable cells: mathematical modeling.The Journal of membrane biology · 2006Article
- Ryanodine receptors in peritoneal mast cells: possible role in the modulation of exocytotic activity.Pflugers Archiv : European journal of physiology · 2004Article
- Angiotensin and calcium signaling in the pituitary and hypothalamus.Cellular and molecular neurobiology · 2002Review
- Endoplasmic reticulum Ca2+-ATPase pump is up-regulated in calcium-transporting dental enamel cells: a non-housekeeping role for SERCA2b.The Biochemical journal · 2001Article
- Microdomains of high calcium are not required for exocytosis in RBL-2H3 mucosal mast cells.The Journal of cell biology · 2001Article
- Mitochondria as all-round players of the calcium game.The Journal of physiology · 2000Review
- Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites.The Biochemical journal · 2000Article
- Fusion of endosomes involved in synaptic vesicle recycling.Molecular biology of the cell · 1999Article
- Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge in Toxoplasma gondii.The Biochemical journal · 1999Article
- Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.The Journal of cell biology · 1999Article
- Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi.The EMBO journal · 1998Article
- PDMP blocks brefeldin A-induced retrograde membrane transport from golgi to ER: evidence for involvement of calcium homeostasis and dissociation from sphingolipid metabolism.The Journal of cell biology · 1998Article
- Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells.Molecular biology of the cell · 1998Article
- Ca2+ homeostasis in the endoplasmic reticulum: coexistence of high and low [Ca2+] subcompartments in intact HeLa cells.The Journal of cell biology · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The functional characteristics of a nonacidic, inositol 1,4,5-trisphosphate- and thapsigargin-insensitive Ca2+ pool have been characterized in mammalian cells derived from the rat pituitary gland (GH3, GC, and GH3B6), the adrenal tissue (PC12), and mast cells (RBL-1). This Ca2+ pool is released into the cytoplasm by the Ca2+ ionophores ionomycin or A23187 after the discharge of the inositol 1,4,5-trisphosphate-sensitive store with an agonist coupled to phospholipase C activation and/or thapsigargin. The amount of Ca2+ trapped within this pool increased significantly after a prolonged elevation of intracellular Ca2+ concentration elicited by activation of Ca2+ influx. This pool was affected neither by caffeine-ryanodine nor by mitochondrial uncouplers. Probing mitochondrial Ca2+ with recombinant aequorin confirmed that this pool did not coincide with mitochondria, whereas its homogeneous distribution across the cytosol, as revealed by confocal microscopy, and its insensitivity to brefeldin A make localization within the Golgi complex unlikely. A proton gradient as the driving mechanism for Ca2+ uptake was excluded since ionomycin is inefficient in releasing Ca2+ from acidic pools and Ca2+ accumulation/release in/from this store was unaffected by monensin or NH4Cl, drugs known to collapse organelle acidic pH gradients. Ca2+ sequestration inside this pool, thus, may occur through a low-affinity, high-capacity Ca2+-ATPase system, which is, however, distinct from classical endosarcoplasmic reticulum Ca2+-ATPases. The cytological nature and functional role of this Ca2+ storage compartment are discussed.
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