ArticleThe Journal of cell biology1997
Identification of a mid-anaphase checkpoint in budding yeast.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed.
- Mechanisms of nuclear segregation in a multinucleate multibudding yeast.The Journal of cell biology · 2025Article
- Expansion microscopy reveals characteristic ultrastructural features of pathogenic budding yeast species.Journal of cell science · 2024Article
- Broken chromosomes heading into mitosis: More than one way to patch a flat tire.The Journal of cell biology · 2024Review
- Tools for live-cell imaging of cytoskeletal and nuclear behavior in the unconventional yeast,Molecular biology of the cell · 2024Article
- Dicentric chromosomes are resolved through breakage and repair at their centromeres.Chromosoma · 2024Article
- Article
- Budding yeast complete DNA synthesis after chromosome segregation begins.Nature communications · 2020Article
- Article
- How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice.Cells · 2019Review
- The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.Nature cell biology · 2016Article
- Maintaining Genome Stability in Defiance of Mitotic DNA Damage.Frontiers in genetics · 2016Review
- Article
- Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly.Molecular biology of the cell · 2013Article
- Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast.The Journal of cell biology · 2013Article
- Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2.PLoS genetics · 2012Article
- Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring.The Journal of cell biology · 2011Article
- Abnormal micronuclear telomeres lead to an unusual cell cycle checkpoint and defects in Tetrahymena oral morphogenesis.Eukaryotic cell · 2008Article
- Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55.Molecular and cellular biology · 2007Article
- Molecular architecture of a kinetochore-microtubule attachment site.Nature cell biology · 2006Article
- Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4.Molecular biology of the cell · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Activation of a facultative, dicentric chromosome provides a unique opportunity to introduce a double strand DNA break into a chromosome at mitosis. Time lapse video enhanced-differential interference contrast analysis of the cellular response upon dicentric activation reveals that the majority of cells initiates anaphase B, characterized by pole-pole separation, and pauses in mid-anaphase for 30-120 min with spindles spanning the neck of the bud before completing spindle elongation and cytokinesis. The length of the spindle at the delay point (3-4 microm) is not dependent on the physical distance between the two centromeres, indicating that the arrest represents surveillance of a dicentric induced aberration. No mid-anaphase delay is observed in the absence of the RAD9 checkpoint gene, which prevents cell cycle progression in the presence of damaged DNA. These observations reveal RAD9-dependent events well past the G2/M boundary and have considerable implications in understanding how chromosome integrity and the position and state of the mitotic spindle are monitored before cytokinesis.
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Registered trials
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