ArticleThe Journal of cell biology1997
Targeting of an intestinal apical endosomal protein to endosomes in nonpolarized cells.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Stepwise Evolution of Coral Biomineralization Revealed with Genome-Wide Proteomics and Transcriptomics.PloS one · 2016Article
- Endosomal regulation of contact inhibition through the AMOT:YAP pathway.Molecular biology of the cell · 2015Article
- Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.Cell metabolism · 2013Article
- Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Rab14 regulates apical targeting in polarized epithelial cells.Traffic (Copenhagen, Denmark) · 2008Article
- Augmented internalisation of ferroportin to late endosomes impairs iron uptake by enterocyte-like IEC-6 cells.Pflugers Archiv : European journal of physiology · 2005Article
- Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells.The Journal of cell biology · 2001Article
- EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts.Molecular biology of the cell · 2000Article
- ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells.The Journal of cell biology · 1999Article
- Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics.The Journal of cell biology · 1999Article
- Biosynthesis of endotubin: an apical early endosomal glycoprotein from developing rat intestinal epithelial cells.The Biochemical journal · 1998Article
- GLUT4 and transferrin receptor are differentially sorted along the endocytic pathway in CHO cells.The Journal of cell biology · 1998Article
- ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway.The Journal of cell biology · 1997Article
- Ricin and viscumin bind to different sites of the cell membrane.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Polarized cells such as epithelial cells and neurons have distinct endosomal compartments associated with different plasma membrane domains. The endosomes of the neuronal cell body and the basolateral cytoplasm of epithelial cells are thought to perform cellular "housekeeping" functions such as the uptake of nutrients and metabolites, while the endosomes in the apical cytoplasm or axons are thought to be specialized for the sorting and transcytosis of cell type-specific ligands and receptors. However, it is not known if nonpolarized cells such as fibroblasts contain a specialized endosomal compartment analogous to the specialized endosomes found in neurons and epithelia. We have expressed a protein that is normally found in the apical early endosomes of developing intestinal epithelial cells in normal rat kidney fibroblasts. This apical endosomal marker, called endotubin, is targeted to early endosomes in transfected fibroblasts, and is present in peripheral as well as perinuclear endosomes. The peripheral endosomes that contain endotubin appear to exclude transferrin, fluid phase markers, and the mannose-6-phosphate receptor, although in the perinuclear region colocalization of endotubin and these markers is present. In addition, endotubin positive structures do not tubulate in response to brefeldin A and instead redistribute to a diffuse perinuclear location. Since this endosomal compartment has many of the characteristics of an apical or axonal endosomal compartment, our results indicate that nonpolarized cells also contain a specialized early endosomal compartment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.