ArticleAnnals of the rheumatic diseases1996
Annexin V autoantibodies in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren's Syndrome-Susceptible C57BL/6.NOD-International journal of molecular sciences · 2022Article
- Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.Science advances · 2020Article
- Biomarkers in Vasculitides of the Nervous System.Frontiers in neurology · 2019Review
- Annexins in Translational Research: Hidden Treasures to Be Found.International journal of molecular sciences · 2018Review
- Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis.Journal of translational medicine · 2016Review
- Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction.Thrombosis journal · 2009Article
- Antiphospholipid antibodies: paradigm in transition.Journal of neuroinflammation · 2009Review
- Immunoproteomic identification of bovine pericardium xenoantigens.Biomaterials · 2008Article
- Amplification of autoimmune disease by infection.Arthritis research & therapy · 2005Review
- Apoptosis-detecting radioligands: current state of the art and future perspectives.European journal of nuclear medicine and molecular imaging · 2004Review
- Antiannexin V autoantibody in thrombophilic Behçet's disease.Rheumatology international · 2004Article
- Anti-annexin V antibodies in Takayasu's arteritis: prevalence and relationship with disease activity.Clinical and experimental immunology · 2003Article
- Mouse annexin V genomic organization includes an endogenous retrovirus.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the occurrence of anti-annexin V autoantibodies in sera of patients with rheumatoid arthritis to assess involvement with the disease and any relation to glucocorticoid treatment.
methodsAnti-annexin V antibodies were measured by an enzyme linked immunosorbent assay (ELISA) which used the purified human recombinant protein as antigen.
resultsConcentrations of anti-annexin V autoantibodies, predominantly of the IgG class, were significantly raised in sera from patients with rheumatoid arthritis compared to normal controls. This was not correlated with other indices of disease activity such as erythrocyte sedimentation rate or C reactive protein and was unrelated to glucocorticoid treatment.
conclusionsExtracellular annexin V provides an antigenic stimulus for autoantibody production and its in vivo expression is independent of glucocorticoid control. Such autoantibodies may have a detrimental role in the arthritic condition by interfering with putative functions of annexin V, including collagen type II binding, inhibition of phospholipase A2 activity, and Fc receptor activity.
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