ArticleThe Plant cell1997
Hexokinase as a sugar sensor in higher plants.
Article in The Plant cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 301 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
301 citing papers in PubMed, 871 citations in OpenAlex.
- The old nourishes the new: 100 years of leaf senescence studies in Plant Physiology.Plant physiology · 2026Review
- FabHLH130-FaSPS1/FaINV positively contributes to the sugar accumulation in strawberry fruits.BMC plant biology · 2026Article
- Hexokinase 1 facilitates post-germinative seedling growth through its catalytic function.The Plant journal : for cell and molecular biology · 2026Article
- The Road so Far: Tracing the Molecular Evolution of Hexokinase Family in Metazoa.Genome biology and evolution · 2026Article
- SWEET1-mediated glucose transport is crucial for energy availability in Arabidopsis.The New phytologist · 2026Article
- Integrated transcriptomic and metabolomic analyses reveal biphasic thermal adaptation strategies inPeerJ · 2026Article
- Simultaneous Knockout of Tk1-SST and Tk1-FFT via CRISPR/Cas9 Enhances the Natural Rubber Accumulation in Taraxacum kok-saghyz.Plant biotechnology journal · 2025Article
- Revisiting the Glucose Kinase Superfamily: From Origins to the Evolution of Metabolism.Genome biology and evolution · 2025Article
- cis- and trans-elements for the transcriptional regulation of sugar responsive genes: from current knowledge to future applications.Plant molecular biology · 2025Review
- The negative responses and acclimation mechanisms of Neopyropia yezoensis conchocelis filaments to short- and long-term ocean acidification.BMC plant biology · 2025Article
- Comparing hormone dynamics in cereal crops via transient expression of hormone sensors.Plant & cell physiology · 2025Article
- Article
- Costs of photosynthesis and cellular remodeling in trophic transitions of the unicellular red alga Galdieria partita.Communications biology · 2025Article
- Crosstalk Between Ethylene and JA/ABA/Sugar Signalling in Plants Under Physiological and Stress Conditions.Molecular plant pathology · 2025Review
- Trichome development of systemic developing leaves is regulated by a nutrient sensor-relay mechanism within mature leaves.Science advances · 2025Article
- OsFKBP12 transduces the sucrose signal from OsNIN8 to the OsTOR pathway in a loosely binding manner for cell division.iScience · 2025Article
- A linker histone acts as a transcription factor to orchestrate malic acid accumulation in apple in response to sorbitol.The Plant cell · 2024Article
- Sugar Transport and Signaling in Shoot Branching.International journal of molecular sciences · 2024Review
- The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast.Epigenetics & chromatin · 2024Article
- A neutral invertase controls cell division besides hydrolysis of sucrose for nutrition during germination and seed setting in rice.iScience · 2024Article
241 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms by which higher plants recognize and respond to sugars are largely unknown. Here, we present evidence that the first enzyme in the hexose assimilation pathway, hexokinase (HXK), acts as a sensor for plant sugar responses. Transgenic Arabidopsis plants expressing antisense hexokinase (AtHXK) genes are sugar hyposensitive, whereas plants overexpressing AtHXK are sugar hypersensitive. The transgenic plants exhibited a wide spectrum of altered sugar responses in seedling development and in gene activation and repression. Furthermore, overexpressing the yeast sugar sensor YHXK2 caused a dominant negative effect by elevating HXK catalytic activity but reducing sugar sensitivity in transgenic plants. The result suggests that HXK is a dual-function enzyme with a distinct regulatory function not interchangeable between plants and yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.