ArticleInternational journal of pancreatology : official journal of the International Association of Pancreatology1996
Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats.
Article in International journal of pancreatology : official journal of the International Association of Pancreatology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Apheresis Technique for Acute Hyperlipidemic Pancreatitis: A Systemic Review and Meta-Analysis.Digestive diseases and sciences · 2023Pooled it
- Systematic review of diet in the pathogenesis of acute pancreatitis: a tale of too much or too little?Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial.Gene therapy · 2013Trial
- Formalized therapeutic guideline for hyperlipidemic severe acute pancreatitis.World journal of gastroenterology · 2003Trial
- Risk factors for disease severity in hypertriglyceridemic acute pancreatitis: a single-center retrospective study.BMC gastroenterology · 2026Article
- Diabetic Ketoacidosis Unveiling Severe Hypertriglyceridemia and Acute Mild Pancreatitis: A Rare Initial Manifestation of Type 2 Diabetes Mellitus.The American journal of case reports · 2026Article
- Development and validation of a 24-h predictive model for hypertriglyceridemic moderately severe acute pancreatitis: a single-center retrospective study.Frontiers in medicine · 2026Article
- Recognition and management of persistent chylomicronemia: A joint expert clinical consensus by the National Lipid Association and the American Society for Preventive Cardiology.American journal of preventive cardiology · 2025Article
- Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis.Digestive diseases and sciences · 2024Article
- Acute Pancreatitis during and after Pregnancy: A Review.Journal of clinical medicine · 2024Review
- Article
- Genetics and Genomics of Chronic Pancreatitis with a Focus on Disease Biology and Molecular Pathogenesis.Global medical genetics · 2023Review
- Acute Pancreatitis, Hypertriglyceridemia, and Diabetic Ketoacidosis: A Life-Threatening Triad.Cureus · 2023Article
- Hypertriglyceridemia with pancreatitis at disease onset in systemic lupus erythematosus.BMJ case reports · 2023Article
- Hyperlipemia pancreatitis onset time affects the association between elevated serum triglyceride levels and disease severity.Lipids in health and disease · 2022Article
- Article
- Hypertriglyceridemia-induced acute pancreatitis in children: A mini-review.Frontiers in pediatrics · 2022Review
- Article
- Diabetic ketoacidosis with acute severe hypertriglyceridaemia-induced pancreatitis as first presentation of type 2 diabetes.BMJ case reports · 2021Article
- Incidence and Management of Hypertriglyceridemia-Associated Acute Pancreatitis: A Prospective Case Series in a Single Australian Tertiary Centre.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
conclusionThe pancreatic damage initiated via different pathogenetic pathways can be increased by triglycerides. Thus, triglycerides seem to play an important role in the pathogenesis of acute pancreatitis.
backgroundLipolytic enzymes and their substrates may play a role in the pathogenesis of acute necrotizing pancreatitis. We investigated, therefore, whether triglycerides alter the course of acute pancreatitis in three experimental models of rats.
methods1. Edematous acute pancreatitis induced by repeated sc injections of cerulein; 2. Necrotizing acute pancreatitis by retrograde duct injection of sodium taurocholate; and 3. Pancreatic edema by ligation of: a. The bile duct at the liver hilus; b. The common bile/pancreatic duct close to the duodenal wall; or c. A combination of a. and b. Six hours later, rats were sacrificed and the isolated perfused pancreas prepared. The pancreases were perfused with either HEPES/Ringer/HAES alone or in combination with various concentrations of triglycerides (1-5% wt/vol). The activities of lipase and amylase in the portal venous effluents were regarded as a marker of pancreatic injury. In addition, the pancreases were evaluated by light microscopy.
resultsIn both cerulein and taurocholate acute pancreatitis, amylase/lipase activities were significantly higher compared to controls during 45 min of perfusion. In both models, addition of triglycerides caused a dose-dependent marked elevation of enzymes. Ligation (a) did not cause any rise in enzymes in the venous effluent; triglycerides had no effect. Ligation (b) or (c) caused a significant increase of pancreatic enzymes, which was further increased by triglycerides. Histology showed various degrees of severity of tissue damage depending on the model used. The additional damaging effect of a 45-min perfusion with triglycerides, however, could not be detected by histology.
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