ArticleProceedings of the National Academy of Sciences of the United States of America1997
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 172 citations in OpenAlex.
- Increasing Specificity of Targeted DNA Methylation Editing by Non-Enzymatic CRISPR/dCas9-Based Steric Hindrance.Biomedicines · 2023Review
- Enzyme-free targeted DNA demethylation using CRISPR-dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression.Nature protocols · 2022Review
- Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.PloS one · 2019Article
- DNA demethylation and invasive cancer: implications for therapeutics.British journal of pharmacology · 2015Review
- CHST11 gene expression and DNA methylation in breast cancer.International journal of oncology · 2015Article
- CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing.Oncogene · 2015Article
- Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation.Cell reports · 2014Article
- Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).Experimental and molecular pathology · 2014Article
- Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.Carcinogenesis · 2014Article
- The dynamic nature of DNA methylation: a role in response to social and seasonal variation.Integrative and comparative biology · 2014Review
- RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation.Cell cycle (Georgetown, Tex.) · 2014Article
- DNA methyltransferases: a novel target for prevention and therapy.Frontiers in oncology · 2014Review
- Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.The Journal of biological chemistry · 2013Article
- Derepression of Cancer/testis antigens in cancer is associated with distinct patterns of DNA hypomethylation.BMC cancer · 2013Article
- An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes.PloS one · 2013Article
- Article
- Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.Carcinogenesis · 2011Article
- 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.Cancer research · 2011Article
- DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.Cancer science · 2010Article
- DNA demethylating antineoplastic strategies: a comparative point of view.Genes & cancer · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper tests the hypothesis that cytosine DNA methyltransferase (DNA MeTase) is a candidate target for anticancer therapy. Several observations have suggested recently that hyperactivation of DNA MeTase plays a critical role in initiation and progression of cancer and that its up-regulation is a component of the Ras oncogenic signaling pathway. We show that a phosphorothioate-modified, antisense oligodeoxynucleotide directed against the DNA MeTase mRNA reduces the level of DNA MeTase mRNA, inhibits DNA MeTase activity, and inhibits anchorage independent growth of Y1 adrenocortical carcinoma cells ex vivo in a dose-dependent manner. Injection of DNA MeTase antisense oligodeoxynucleotides i.p. inhibits the growth of Y1 tumors in syngeneic LAF1 mice, reduces the level of DNA MeTase, and induces demethylation of the adrenocortical-specific gene C21 and its expression in tumors in vivo. These results support the hypothesis that an increase in DNA MeTase activity is critical for tumorigenesis and is reversible by pharmacological inhibition of DNA MeTase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.