ArticleProceedings of the National Academy of Sciences of the United States of America1997
Effects of methionine on the cytoplasmic distribution of actin and tubulin during neural tube closure in rat embryos.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- Abnormal methylation caused by folic acid deficiency in neural tube defects.Open life sciences · 2022Review
- Homocysteine Metabolism in Pregnancy and Developmental Impacts.Frontiers in cell and developmental biology · 2022Review
- The effect of methionine and folic acid administered in ovo on the hematological parameters of chickens (Gallus gallus domesticus).Poultry science · 2020Article
- Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density.Birth defects research · 2019Article
- Trends in folic acid supplementation during pregnancy - the effect on allergy development in children.Postepy dermatologii i alergologii · 2018Article
- Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.Cell reports · 2017Article
- Neural tube defects, folic acid and methylation.International journal of environmental research and public health · 2013Review
- Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.Journal of inherited metabolic disease · 2011Review
- Effects of folic acid and homocysteine on spinal cord morphology of the chicken embryo.Histochemistry and cell biology · 2009Article
- Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.International journal of cancer · 2009Article
- In utero supplementation with methyl donors enhances allergic airway disease in mice.The Journal of clinical investigation · 2008Article
- Apical accumulation of MARCKS in neural plate cells during neurulation in the chick embryo.BMC developmental biology · 2001Article
- Nerve growth factor-specific regulation of protein methylation during neuronal differentiation of PC12 cells.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Research has previously shown that, without methionine supplements, neural tube proteins of rat embryos cultured on bovine sera were hypomethylated and neural tubes failed to close. In the present study, to identify the proteins that became methylated during neurulation, rat embryos were first cultured on methionine-deficient bovine serum for 40 hr, then incubated with puromycin for 1 hr, and, finally, incubated with [methyl-14C]methionine and puromycin for 5 hr. On the basis of molecular weights, isoelectric points, and Western immunoblots, the methyl-14C-labeled proteins were identified as actin, alpha beta-tubulin, and neurofilament L. Indirect immunofluorescence studies indicated that without the addition of methionine to the culture, localization of actin and alpha beta-tubulin in the basal cytoplasm did not occur and these neuroepithelial cells lost their columnar morphology.
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Registered trials
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