ArticleAmerican journal of human genetics1997
Sequence variation at the phenylalanine hydroxylase gene in the British Isles.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Association Between PAH Mutations and VNTR Alleles in the West Azerbaijani PKU Patients.Maedica · 2014Article
- mtDNA and the origin of the Icelanders: deciphering signals of recent population history.American journal of human genetics · 2000Article
- Phenylketonuria in Britain: genetic analysis gives a historical perspective of the disorder but will it predict the future for affected individuals?Molecular pathology : MP · 1997Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Using mutation and haplotype analysis, we have examined the phenylalanine hydroxylase gene in the phenylketonuria populations of four geographical areas of the British Isles: the west of Scotland, southern Wales, and southwestern and southeastern England. The enormous genetic diversity of this locus within the British Isles is demonstrated in the large number of different mutations characterized and in the variety of genetic backgrounds on which individual mutations are found. Allele frequencies of the more common mutations exhibited significant nonrandom distribution in a north/south differentiation. Differences between the west of Scotland and southwestern England may be related to different events in the recent and past histories of their respective populations. Similarities between southern Wales and southeastern England are likely to reflect the heterogeneity that is seen in and around two large capital cities. Finally, comparison with more recently colonized areas of the world corroborates the genealogical origin by range expansion of several mutations.
Indexed as
Identifiers
9012412PMC1712390What OpenQuestion holds
Registered trials
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