ArticleAmerican journal of human genetics1997
Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Family-based analysis identified CD2 as a susceptibility gene for primary open angle glaucoma in Chinese Han population.Journal of cellular and molecular medicine · 2014Pooled it
- Article
- Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma.Indian journal of ophthalmology · 2021Article
- Normal and glaucomatous outflow regulation.Progress in retinal and eye research · 2021Review
- Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.Molecular vision · 2019Article
- Major review: Molecular genetics of primary open-angle glaucoma.Experimental eye research · 2017Review
- Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.Progress in retinal and eye research · 2017Review
- The Role of the IL-20 Subfamily in Glaucoma.Mediators of inflammation · 2016Review
- Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins.Investigative ophthalmology & visual science · 2014Article
- Genetics of primary open angle glaucoma.Japanese journal of ophthalmology · 2014Review
- A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.PloS one · 2013Article
- Variants in ASB10 are associated with open-angle glaucoma.Human molecular genetics · 2012Article
- Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment.Eye (London, England) · 2012Review
- Common TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma.Molecular vision · 2012Article
- Current gene discovery strategies for ocular conditions.Investigative ophthalmology & visual science · 2011Review
- Racial differences in ocular oxidative metabolism: implications for ocular disease.Archives of ophthalmology (Chicago, Ill. : 1960) · 2011Article
- Complex genetic mechanisms in glaucoma: an overview.Indian journal of ophthalmology · 2011Review
- Genome-wide linkage scan for primary open angle glaucoma: influences of ancestry and age at diagnosis.PloS one · 2011Article
- Copy number variations and primary open-angle glaucoma.Investigative ophthalmology & visual science · 2011Article
- Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses.Molecular vision · 2010Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C.
Indexed as
Identifiers
9012402PMC1712411What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.