ArticleThe Journal of physiology1996
Rapid activation of KATP channels by aldosterone in principal cells of frog skin.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 43 citations in OpenAlex.
- Genomic and rapid effects of aldosterone: what we know and do not know thus far.Heart failure reviews · 2017Review
- Vasotocin has the potential to inhibit basolateral Na(+)/K (+)-pump current across isolated skin of tree frog in vitro, via its V(2)-type receptor/cAMP pathway.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
- Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium.The Journal of physiology · 2001Article
- Rapid activation of basolateral potassium transport in human colon by oestradiol.British journal of pharmacology · 2000Article
- Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells.The Journal of physiology · 1998Article
- Nitric oxide links the apical Na+ transport to the basolateral K+ conductance in the rat cortical collecting duct.The Journal of general physiology · 1997Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. In epithelial cells of frog skin, potassium ions are recycled across the basolateral membrane via an inward-rectifier, ATP-sensitive K+ channel (KATP channel). In this study, we show that aldosterone has a stimulatory effect on KATP channel activity and we have investigated the involvement of Na+-H+ exchange and intracellular pH (pHi) in this phenomenon. 2. Aldosterone (10 nM) produced an increase in the open probability of the KATP channel within 15 min from 0.21 +/- 0.05 to 0.93 +/- 0.10 (n = 8), measured in cell-attached patches. Aldosterone also increased the tolbutamide-sensitive K+ current across the basolateral membrane within 30 min from 17.2 +/- 1.9 to 30.3 +/- 1.6 microA cm-2 (n = 8) in nystatin-permeabilized whole skins. 3. The KATP channel is very sensitive to variations in cytosolic pH within the physiological range 7.0-7.4. 4. The intracellular pH of principal cells is regulated by Na+-H+ exchange, and the stimulatory effect of aldosterone on KATP channel activity was abolished by amiloride (100 microM) added on the basolateral side of the epithelium either before or after aldosterone treatment. 5. We propose that aldosterone activates the KATP channels via stimulation of Na+-H+ exchange. The rapidity of aldosterone activation of KATP channels is presented as evidence for a novel non-genomic steroid hormone effect on epithelial ion transport.
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