ArticleThe Journal of clinical investigation1997
Mutation of human keratin 18 in association with cryptogenic cirrhosis.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 113 citations in OpenAlex.
- Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain.International journal of molecular sciences · 2020Article
- Incidental medical information in whole-exome sequencing.Pediatrics · 2012Article
- Cryptogenic chronic hepatitis and its changing guise in adults.Digestive diseases and sciences · 2011Review
- Review
- Defining Molecular Phenotypes of Mesenchymal and hematopoietic Stem Cells derived from Peripheral blood of Acute Lymphocytic Leukemia patients for regenerative stem cell therapy.Journal of stem cells & regenerative medicine · 2011Article
- Establishment and molecular characterization of mesenchymal stem cell lines derived from human visceral & subcutaneous adipose tissues.Journal of stem cells & regenerative medicine · 2010Article
- Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.Toxicology and applied pharmacology · 2009Article
- Toward unraveling the complexity of simple epithelial keratins in human disease.The Journal of clinical investigation · 2009Review
- "IF-pathies": a broad spectrum of intermediate filament-associated diseases.The Journal of clinical investigation · 2009Review
- A disease- and phosphorylation-related nonmechanical function for keratin 8.The Journal of cell biology · 2006Article
- Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice.Comparative hepatology · 2004Article
- Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells.Molecular and cellular biology · 2004Article
- Keratin 20 helps maintain intermediate filament organization in intestinal epithelia.Molecular biology of the cell · 2003Article
- Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Genetic disorders of palm skin and nail.Journal of anatomy · 2003Review
- Bile acid-induced Mallory body formation in drug-primed mouse liver.The American journal of pathology · 2002Article
- Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments.Molecular biology of the cell · 2002Article
- Increased levels of keratin 16 alter epithelialization potential of mouse skin keratinocytes in vivo and ex vivo.Molecular biology of the cell · 2001Article
- Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD.The Journal of cell biology · 2001Article
- Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies.The American journal of pathology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Mutations in 11 of the more than 20 keratin intermediate filaments cause several epidermal and oral associated diseases. No disease-associated mutations have been described in keratin 8 or 18 (K8/18) which are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. However, transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increased susceptibility to drug-induced hepatotoxicity. Also, ectopic expression of epidermal K14 in mouse liver results in chronic hepatitis, and disruption of mouse K8 leads to embryo lethality with extensive liver hemorrhage. We tested if patients with liver disease of unknown cause may harbor mutations in K18. We describe a his127-->leu (H127L) K18 mutation in a patient with cryptogenic cirrhosis that is germline transmitted. The K18 H127L isolated from the liver explant, or after expression in bacteria, showed an altered migration on two-dimensional gel analysis as compared with normal human liver or bacterially expressed K18. Electron microscopy of in vitro assembled K18 H127L and wild type K8 showed an assembly defect as compared with normal K8/18 assembly. Our results suggest that mutations in K18 may be predispose to, or result in cryptogenic cirrhosis in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.