ArticleJournal of neurology, neurosurgery, and psychiatry1997
The stiff leg syndrome.
Article in Journal of neurology, neurosurgery, and psychiatry, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Childhood onset of stiff-man syndrome.JAMA neurology · 2013Pooled it
- GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.Diabetologia · 2009Trial
- Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Stiff-Leg Syndrome Associated with Autoimmune Retinopathy and Its Treatment with IVIg-A Case Report and Review of the Literature.Brain sciences · 2023Review
- GAD antibodies in neurological disorders - insights and challenges.Nature reviews. Neurology · 2020Review
- Functional gait disorders: A sign-based approach.Neurology · 2020Review
- Article
- The clinical features, underlying immunology, and treatment of autoantibody-mediated movement disorders.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Clinical and Immunologic Investigations in Patients With Stiff-Person Spectrum Disorder.JAMA neurology · 2016Article
- Review
- Antiglycine receptor-related stiff limb syndrome in a patient with chronic lymphocytic leukaemia.BMJ case reports · 2013Article
- Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype.JAMA neurology · 2013Article
- Stiff-man syndrome in childhood.Journal of the Royal Society of Medicine · 2001Article
- Stiff man syndrome.CNS drugs · 2001Review
- Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity.Journal of neurology, neurosurgery, and psychiatry · 1998Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four patients had a chronic progressive disorder beginning in middle age and involving stiffness and painful spasms of the lower limbs. Spasms were spontaneous, reflex, and induced by voluntary movement. Patients had rigidity and abnormal postures of one or both legs. There was no truncal rigidity or exaggerated lumbar lordosis. Despite the presence of symptoms for up to 16 years, symptoms and signs of brainstem, pyramidal, and sensory dysfunction were absent. Sphincter disturbance developed after many years in one patient. Extensive investigation, including imaging of the whole neuroaxis, failed to disclose a cause. Anti-GAD antibodies were absent. Baclofen and diazepam led to some reduction in the painful spasms, but patients remained disabled by the condition. There were four core electrophysiological features. (1) Continuous motor unit activity was present at rest in at least one limb muscle. (2) Spasms tended to involve the repetitive grouped discharge of motor units. (3) Cutaneomuscular reflexes were abnormal. (4) There was little or no electrophysiological evidence of long tract disturbance. The patients form a characteristic syndrome, separate from the stiff man syndrome, and distinguishable from encephalomyelitis with rigidity. It is suggested that the condition is due to a chronic spinal interneuronitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.