ArticleBritish journal of cancer1997
Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- The association between BMI and kidney cancer risk: An updated dose-response meta-analysis in accordance with PRISMA guideline.Medicine · 2018Pooled it
- Trends and etiological profile of kidney cancer in China from 1990 to 2023: an analysis of modifiable risk factors and prevention implications using GBD 2023 estimates.International journal of clinical oncology · 2026Review
- The Role of Metabolic Factors in Renal Cancers.International journal of molecular sciences · 2020Review
- Timing of breast cancer surgery during the menstrual cycle-is there an optimal time of the month?Oncology letters · 2020Review
- Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Emerging targeted agents in metastatic breast cancer.Nature reviews. Clinical oncology · 2013Review
- Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.Molecular and cellular endocrinology · 2012Article
- An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma.Journal of translational medicine · 2012Article
- Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells.Experimental cell research · 2010Article
- Regulation of MDMX expression by mitogenic signaling.Molecular and cellular biology · 2008Article
- Does the timing of breast cancer surgery in pre-menopausal women affect clinical outcome? An update.International seminars in surgical oncology : ISSO · 2006Article
- Role of insulin-like growth factor 1 receptor signalling in cancer.British journal of cancer · 2005Review
- Breast cancer prevention trials using retinoids.Journal of mammary gland biology and neoplasia · 2003Review
- Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function.Breast cancer research : BCR · 2002Review
- Xenograft models of premalignant breast disease.Journal of mammary gland biology and neoplasia · 2000Review
- Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line.British journal of cancer · 1999Article
- The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland.Journal of mammary gland biology and neoplasia · 1998Review
- Estrogen responsiveness and control of normal human breast proliferation.Journal of mammary gland biology and neoplasia · 1998Review
- Breast cancer: further metabolic-endocrine risk markers?British journal of cancer · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epithelial proliferation of normal human breast tissue xenografts implanted into athymic nude mice is significantly increased from basal levels by oestradiol (E2), but not progesterone (Pg) treatment at serum concentrations similar to those observed in the luteal phase of the human menstrual cycle. Type I IGF receptor (IGFR-I) mRNA and protein have been shown to be up-regulated by E2 in MCF-7 breast cancer cells in vitro in which IGF-I and E2 act synergistically to stimulate proliferation. We have investigated the expression of the IGFR-I mRNA in normal human breast xenografts treated with or without E2 or Pg alone and in combination. Northern analysis of 20 micrograms of RNA extracted from the breast xenograft samples showed no hybridization with 32P-labelled IGFR-I probe, although an 11-kb species of IGFR-I mRNA could be seen when 20 micrograms of RNA extracted from either MCF-7 breast cancer cells or human breast carcinomas was examined in this way. In order to analyse the expression of IGFR-I mRNA in breast xenografts, a quantitative reverse transcription-polymerase chain reaction (RT-PCR) was employed in which RNA loading, reverse transcription and PCR efficiencies were internally controlled. The data indicate that the IGFR-I mRNA is up-regulated by two to threefold compared with untreated levels by 7 and 14 days E2 treatment. In contrast, 7 or 14 days Pg treatment down-regulates the receptor mRNA to approximately half that of untreated levels, whereas combination E2 and Pg treatment produced a twofold increase in IGFR-I mRNA levels compared with untreated tissue. The results are consistent with the suggestion that E2 may act to stimulate proliferation indirectly via a paracrine mechanism involving IGFs in normal as well as malignant human breast epithelial cells.
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