ArticleInfection and immunity1997
Nramp1 transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on antigen processing and presentation.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Defining solute carrier transporter signatures of murine immune cell subsets.Frontiers in immunology · 2023Article
- SLC11A1 (rs3731865) polymorphism and susceptibility to visceral leishmaniasis in HIV-coinfected patients from Northeastern Brazil.Parasitology research · 2020Article
- Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo.PLoS pathogens · 2015Article
- Transport of magnesium by a bacterial Nramp-related gene.PLoS genetics · 2014Article
- IFNγ expression by an attenuated strain of Salmonella enterica serovar Typhimurium improves vaccine efficacy in susceptible TLR4-defective C3H/HeJ mice.Medical microbiology and immunology · 2013Article
- The functional SLC11A1 gene polymorphisms are associated with sarcoidosis in Turkish population.Molecular biology reports · 2012Article
- Human macrophage response to L. (Viannia) panamensis: microarray evidence for an early inflammatory response.PLoS neglected tropical diseases · 2012Article
- Quantitative PCR-based competitive index for high-throughput screening of Salmonella virulence factors.Infection and immunity · 2011Article
- Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence.Immunogenetics · 2007Review
- Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function.Infection and immunity · 2007Article
- The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer?FEMS immunology and medical microbiology · 2007Review
- Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.BMC medical genetics · 2005Article
- Intracellular adhesion molecule 1 plays a key role in acquired immunity to salmonellosis.Infection and immunity · 2003Article
- Genetics of susceptibility to leprosy.Genes and immunity · 2002Review
- SitABCD is the alkaline Mn(2+) transporter of Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2002Article
- Mapping and sequencing of the canine NRAMP1 gene and identification of mutations in leishmaniasis-susceptible dogs.Infection and immunity · 2002Article
- Atopy in children in relation to BCG vaccination and genetic polymorphisms at SLC11A1 (formerly NRAMP1) and D2S1471.Genes and immunity · 2002Article
- SLC11A1 (formerly NRAMP1) and disease resistance.Cellular microbiology · 2001Review
- Clearance of infection with Mycobacterium bovis BCG in mice is enhanced by treatment with S28463 (R-848), and its efficiency depends on expression of wild-type Nramp1 (resistance allele).Antimicrobial agents and chemotherapy · 2001Article
- Influence of vector-encoded cytokines on anti-Salmonella immunity: divergent effects of interleukin-2 and tumor necrosis factor alpha.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The natural resistance-associated macrophage protein (Nramp1) regulates macrophage activation. One of its pleiotropic effects on macrophage function is to regulate expression of major histocompatibility class II molecules. In this study macrophages stably transfected with the wild-type (infection-resistant) or the natural mutant (infection-susceptible) allele of the Nramp1 gene were used to study class II expression and processing and presentation of recombinant protein antigens to CD4+ T-cell hybridomas. As demonstrated previously for macrophages from Nramp1-resistant and -susceptible congenic mouse strains, transfected macrophage clones carrying the wild-type allele showed enhanced upregulation of class II molecules in response to gamma interferon compared to that shown by macrophage clones carrying an endogenous mutant allele or transfected with the mutant allele expressed under a viral long terminal repeat promoter. The wild-type allele-transfected macrophage clones also demonstrated an enhanced, lipopolysaccharide-dependent ability to process the recombinant leishmanial antigen LACK-delta 1 (the Leishmania homolog of receptors for activated C kinase) for presentation to LACK-specific CD4+ T cells. An influence on antigen processing must therefore be added to the growing list of pleiotropic effects of the Nramp1 gene potentially contributing to its role in infectious and autoimmune disease susceptibility. These results also have important implications for analysis of T-cell responses to vaccination, especially where antigens are presented to the immune system using live Salmonella species or Mycobacterium bovis BCG as a vaccine vehicle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.