ArticleThe EMBO journal1997
Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 117 citations in OpenAlex.
- ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF.Molecular cell · 2025Article
- Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function.Molecular cell · 2025Article
- Exploring the Use of Alternative Promoters for Enhanced Transgene and sgRNA Expression in Atlantic Salmon Cells.Marine biotechnology (New York, N.Y.) · 2024Article
- Molecular Characterization of U6 Promoters from Orange-Spotted Grouper (Epinephelus coioides) and Its Application in DNA Vector-Based RNAi Technology.Marine biotechnology (New York, N.Y.) · 2023Article
- The role of ZNF143 overexpression in rat liver cell proliferation.BMC genomics · 2022Article
- Follistatin treatment modifies DNA methylation of the CDX2 gene in bovine preimplantation embryos.Molecular reproduction and development · 2020Article
- Article
- ZNF143 in Chromatin Looping and Gene Regulation.Frontiers in genetics · 2020Review
- Regulation of expression of human RNA polymerase II-transcribed snRNA genes.Open biology · 2017Review
- Genomic Determinants of THAP11/ZNF143/HCFC1 Complex Recruitment to Chromatin.Molecular and cellular biology · 2015Article
- Genome-wide map of regulatory interactions in the human genome.Genome research · 2014Article
- Improving analysis of transcription factor binding sites within ChIP-Seq data based on topological motif enrichment.BMC genomics · 2014Article
- Identification and characterization of buffalo 7SK and U6 pol III promoters and application for expression of short hairpin RNAs.International journal of molecular sciences · 2014Article
- Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.Nucleic acids research · 2013Article
- The transcriptional activator ZNF143 is essential for normal development in zebrafish.BMC molecular biology · 2012Article
- Article
- Genomic relationship between SINE retrotransposons, Pol III-Pol II transcription, and chromatin organization: the journey from junk to jewel.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011Review
- Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF).The Biochemical journal · 2011Article
- Genome-wide evidence for an essential role of the human Staf/ZNF143 transcription factor in bidirectional transcription.Nucleic acids research · 2011Article
- Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes.Cancer science · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staf is a zinc finger protein that we recently identified as the transcriptional activator of the RNA polymerase III-transcribed selenocysteine tRNA gene. In this work we demonstrate that enhanced transcription of the majority of vertebrate snRNA and snRNA-type genes, transcribed by RNA polymerases II and III, also requires Staf. DNA binding assays and microinjection of mutant genes into Xenopus oocytes showed the presence of Staf-responsive elements in the genes for human U4C, U6, Y4 and 7SK, Xenopus U1b1, U2, U5 and MRP and mouse U6 RNAs. Using recombinant Staf, we established that it mediates the activating properties of Staf-responsive elements on RNA polymerase II and III snRNA promoters in vivo. Lastly a 19 bp consensus sequence for the Staf binding site, YY(A/T)CCC(A/G)N(A/C)AT(G/C)C(A/C)YY-RCR, was derived by binding site selection. It enabled us to identify 23 other snRNA and snRNA-type genes carrying potential Staf binding sites. Altogether, our results emphasize the prime importance of Staf as a novel activator for enhanced transcription of snRNA and snRNA-type genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.