ArticleThe EMBO journal1997
Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 137 citations in OpenAlex.
- Impact of targeting the platelet-activating factor and its receptor in cancer treatment.Military Medical Research · 2025Review
- New Insights Into the Pathologic Roles of the Platelet-Activating Factor System.Frontiers in endocrinology · 2021Review
- The Potential Role of Dietary Platelet-Activating Factor Inhibitors in Cancer Prevention and Treatment.Advances in nutrition (Bethesda, Md.) · 2019Review
- Systemic Platelet-Activating Factor-Receptor Agonism Enhances Non-Melanoma Skin Cancer Growth.International journal of molecular sciences · 2018Article
- Review
- Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.Cell discovery · 2016Article
- Article
- Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells.Journal of hematology & oncology · 2014Article
- Palliation of bone cancer pain by antagonists of platelet-activating factor receptors.PloS one · 2014Article
- Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis.Carcinogenesis · 2012Article
- Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma.Mediators of inflammation · 2012Article
- Article
- The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.Biochimie · 2010Review
- Differential expression of platelet-activating factor acetylhydrolase in lung macrophages.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects.Prostaglandins & other lipid mediators · 2008Review
- Emerging roles of PAR-1 and PAFR in melanoma metastasis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2008Article
- G-protein-coupled receptors and melanoma.Pigment cell & melanoma research · 2008Review
- Platelet-activating factor: a previously unrecognized mediator of fever.The Journal of physiology · 2003Article
- A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4.The American journal of pathology · 2003Article
- PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.The American journal of pathology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although platelet-activating factor (PAF) has been shown to exert pleiotropic effects on isolated cells or tissues, controversy still exists as to whether it plays significant pathophysiological roles in vivo. To answer this question, we established transgenic mice over-expressing a guinea-pig PAF receptor (PAFR). The transgenic mice showed a bronchial hyperreactivity to methacholine and an increased mortality when exposed to bacterial endotoxin. An aberrant melanogenesis and proliferative abnormalities in the skin were also observed in the transgenic mice, some of which spontaneously bore melanocytic tumors in the dermis after aging. Thus, PAFR transgenic mice proved to be a useful model for studying the basic pathophysiology of bronchial asthma and endotoxin-induced death, and screening of therapeutics for these disorders. Furthermore, our findings provide new insights regarding the role of PAF in the morphogenesis of dermal tissues as well as the mitogenic activity of PAF and PAFR in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.