ArticleThe EMBO journal1997
The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 127 citations in OpenAlex.
- PEX14 condensates recruit receptor and cargo pairs for peroxisomal protein import.Nature structural & molecular biology · 2025Article
- Towards solving the mystery of peroxisomal matrix protein import.Trends in cell biology · 2024Review
- Peroxisome function relies on organelle-associated mRNA translation.Science advances · 2022Article
- Yeast Vps13 is Crucial for Peroxisome Expansion in Cells With Reduced Peroxisome-ER Contact Sites.Frontiers in cell and developmental biology · 2022Article
- Structure-function analysis of the ER-peroxisome contact site protein Pex32.Frontiers in cell and developmental biology · 2022Article
- Biomolecule fromPlants (Basel, Switzerland) · 2020Article
- Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host.Proceedings. Biological sciences · 2019Article
- Roles of Peroxisomes in the Rice Blast Fungus.BioMed research international · 2016Review
- Emerging role of the endoplasmic reticulum in peroxisome biogenesis.Frontiers in physiology · 2013Review
- Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down.Genetics · 2013Review
- Article
- Identification of phosphorylation sites in Hansenula polymorpha Pex14p by mass spectrometry.FEBS open bio · 2013Article
- Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments.PloS one · 2013Article
- Visualization of microbodies in Chlamydomonas reinhardtii.Journal of plant research · 2012Article
- Peroxisomal targeting signals in green algae.Protoplasma · 2009Article
- Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Identification of a novel, intraperoxisomal pex14-binding site in pex13: association of pex13 with the docking complex is essential for peroxisomal matrix protein import.Molecular and cellular biology · 2005Article
- Glucose is toxic to glycosome-deficient trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Direct interaction between glyoxysomes and lipid bodies in cotyledons of the Arabidopsis thaliana ped1 mutant.Protoplasma · 2001Article
- Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.Molecular biology of the cell · 2000Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have cloned the Hansenula polymorpha PEX14 gene by functional complementation of the chemically induced pex14-1 mutant, which lacked normal peroxisomes. The sequence of the PEX14 gene predicts a novel protein product (Pex14p) of 39 kDa which showed no similarity to any known protein and lacked either of the two known peroxisomal targeting signals. Biochemical and electron microscopical analysis indicated that Pex14p is a component of the peroxisomal membrane. The synthesis of Pex14p is induced by peroxisome-inducing growth conditions. In cells of both pex14-1 and a PEX14 disruption mutant, peroxisomal membrane remnants were evident; these contained the H.polymorpha peroxisomal membrane protein Pex3p together with a small amount of the major peroxisomal matrix proteins alcohol oxidase, catalase and dihydroxyacetone synthase, the bulk of which resided in the cytosol. Unexpectedly, overproduction of Pex14p in wild-type H. polymorpha cells resulted in a peroxisome-deficient phenotype typified by the presence of numerous small vesicles which lacked matrix proteins; these were localized in the cytosol. Apparently, the stoichiometry of Pex14p relative to one or more other components of the peroxisome biogenesis machinery appears to be critical for protein import.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.