ArticleClinical and diagnostic laboratory immunology1997
Human humoral responses to antigens of Mycobacterium tuberculosis: immunodominance of high-molecular-mass antigens.
Article in Clinical and diagnostic laboratory immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
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- Biomarkers for tuberculosis: the case for lipoarabinomannan.ERJ open research · 2019Review
- Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis.International journal of nanomedicine · 2019Article
- Lipoarabinomannan in Active and Passive Protection Against Tuberculosis.Frontiers in immunology · 2019Review
- Improved Serodiagnostic Sensitivity of Strip Test for Latent Tuberculosis.Journal of clinical and diagnostic research : JCDR · 2017Article
- A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens.Mediators of inflammation · 2015Article
- Transcriptional profiling of Mycobacterium tuberculosis replicating ex vivo in blood from HIV- and HIV+ subjects.PloS one · 2014Article
- Interaction of Mycobacterium leprae with human airway epithelial cells: adherence, entry, survival, and identification of potential adhesins by surface proteome analysis.Infection and immunity · 2013Article
- Effect of mycobacterial secretory proteins on the cellular integrity and cytokine profile of type II alveolar epithelial cells.Lung India : official organ of Indian Chest Society · 2012Article
- The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin.BMC microbiology · 2009Article
- Peptides of a novel Mycobacterium tuberculosis-specific cell wall protein for immunodiagnosis of tuberculosis.The Journal of infectious diseases · 2009Article
- Peptide-based antibody detection for tuberculosis diagnosis.Clinical and vaccine immunology : CVI · 2009Article
- Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country.PloS one · 2008Article
- Humoral immune responses of tuberculosis patients in Brazil indicate recognition of Mycobacterium tuberculosis MPT-51 and GlcB.Clinical and vaccine immunology : CVI · 2008Article
- Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.Infection and immunity · 2007Article
- Immunogenicity of the Mycobacterium tuberculosis PPE55 (Rv3347c) protein during incipient and clinical tuberculosis.Infection and immunity · 2005Article
- Peripheral blood and pleural fluid mononuclear cell responses to low-molecular-mass secretory polypeptides of Mycobacterium tuberculosis in human models of immunity to tuberculosis.Infection and immunity · 2005Article
- Antigens of Mycobacterium tuberculosis recognized by antibodies during incipient, subclinical tuberculosis.Clinical and diagnostic laboratory immunology · 2005Article
- Comparison of antibody responses to a potential combination of specific glycolipids and proteins for test sensitivity improvement in tuberculosis serodiagnosis.Clinical and diagnostic laboratory immunology · 2004Article
- PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The selection of antigens of Mycobacterium tuberculosis for most studies of humoral responses in tuberculosis patients has been restricted to molecules that were either immunodominant in immunized animals or amenable to biochemical purification rather than those that were reactive with the human immune system. Delineation of antigens that elicit humoral responses during the natural course of disease progression in humans has been hindered by the presence of cross-reactive antibodies to conserved regions on ubiquitous prokaryotic antigens in sera from healthy individuals and tuberculosis patients. The levels of cross-reactive antibodies in the sera were reduced by preadsorption with Escherichia coli lysates, prior to studying their reactivity against a large panel of M. tuberculosis antigens to which the human immune system may be exposed during natural infection and disease. Thus, reactivity against pools of secreted, cellular, and cell wall-associated antigens of M. tuberculosis was assessed by an enzyme-linked immunosorbent assay (ELISA). Initial results suggested that the secreted protein preparation contained antigens most frequently recognized by the humoral responses of pulmonary tuberculosis patients. The culture filtrate proteins were subsequently size fractionated by preparative polyacrylamide gel electrophoresis, characterized by reaction with murine monoclonal antibodies to known antigens of M. tuberculosis by an ELISA, and assessed for reactivity with tuberculous and nontuberculous sera. Results show that a secreted antigen of 88 kDa elicits a strong antibody response in a high percentage of patients with pulmonary tuberculosis. This and other antigens identified on the basis of their reactivity with patient sera may prove useful for developing serodiagnosis for tuberculosis.
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