ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Expression and distribution of IGF-1 receptors containing a beta-subunit variant (betagc) in developing neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Insulin and IGF signaling in the brain: multilevel regulation of synaptic and network homeostasis.Frontiers in endocrinology · 2026Review
- Growth Hormone and IGF-1 Actions in the Brain and Neuropsychiatric Diseases.Physiology (Bethesda, Md.) · 2026Review
- Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.Cell discovery · 2015Article
- The insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neurons.PloS one · 2013Article
- Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway.Frontiers in cellular neuroscience · 2013Article
- The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons.Molecular biology of the cell · 2004Article
- Evidence for the involvement of Tiam1 in axon formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Evidence for the involvement of KIF4 in the anterograde transport of L1-containing vesicles.The Journal of cell biology · 2000Article
- Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons.The Journal of cell biology · 1998Article
- Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Betagc is a beta-subunit variant of the insulin-like growth factor-1 (IGF-1) receptor highly enriched in growth cone membranes prepared by subcellular fractionation of fetal rat brain (). The present study is focused on the expression and on the cellular and subcellular distribution of betagc in developing neurons and differentiating PC12 cells. In the developing cerebral cortex and, at least at early stages, in cultured primary neurons, betagc expression was found to be correlated with neurite outgrowth. In PC12 cells betagc expression was nerve growth factor (NGF)-dependent and also paralleled neurite outgrowth. In contrast, beta-subunits of the insulin receptor and/or of other IGF-1 receptors ("betaP5"; detected with antibody AbP5) were downregulated as betagc expression increased. Immunofluorescence studies confirmed the enrichment of betagc at growth cones and demonstrated morphologically its spatial separation from betaP5, which is confined to the perikaryon. At the growth cone, betagc colocalizes and associates in a proximal region with microtubules, but it seems independent of the more peripheral microfilaments. Some betagc immunoreactivity is detected in the perinuclear region of PC12 cells, most likely the Golgi complex and its vicinity. betagc seems to emerge from the periphery of this structure in an apparently vesicular compartment distinct from that carrying synaptophysin to the growth cones. The facts that (1) betagc expression is correlated closely with neurite outgrowth, that (2) it is regulated in PC12 cells by a neurotrophin, NGF, and that (3) betagc is concentrated in the proximal growth cone region raise new questions regarding a possible role of IGF-1 receptors containing betagc in the regulation of neurite growth.
Indexed as
Identifiers
9006986PMC6793729W1558257544What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.