ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
A pacemaker current in dye-coupled hilar interneurons contributes to the generation of giant GABAergic potentials in developing hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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Who cites it
52 citing papers in PubMed.
- Excitatory synchronization of rat hippocampal interneurons during network activationFrontiers in cellular neuroscience · 2023Article
- GAP junctions: multifaceted regulators of neuronal differentiation.Tissue barriers · 2022Article
- Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance.Frontiers in cellular neuroscience · 2021Review
- The effects of developmental alcohol exposure on the neurobiology of spatial processing.Neuroscience and biobehavioral reviews · 2019Review
- Early Correlated Network Activity in the Hippocampus: Its Putative Role in Shaping Neuronal Circuits.Frontiers in cellular neuroscience · 2017Review
- The Subiculum: A Potential Site of Ictogenesis in a Neonatal Seizure Model.Frontiers in neurology · 2017Article
- Interneurons Differentially Contribute to Spontaneous Network Activity in the Developing Hippocampus Dependent on Their Embryonic Lineage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.Hippocampus · 2015Review
- Glutamatergic system controls synchronization of spontaneous neuronal activity in the murine neonatal entorhinal cortex.Pflugers Archiv : European journal of physiology · 2015Article
- GABA receptors in brain development, function, and injury.Metabolic brain disease · 2015Review
- Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.Molecular brain · 2015Article
- The developmental stages of synaptic plasticity.The Journal of physiology · 2014Review
- Neuronal gap junctions: making and breaking connections during development and injury.Trends in neurosciences · 2013Review
- Novel model for the mechanisms of glutamate-dependent excitotoxicity: role of neuronal gap junctions.Brain research · 2012Review
- Distinct perinatal features of the hyperpolarization-activated non-selective cation current I(h) in the rat cortical plate.Neural development · 2012Article
- Modeling developmental patterns of spontaneous activity.Current opinion in neurobiology · 2011Review
- Developmental changes in propagation patterns and transmitter dependence of waves of spontaneous activity in the mouse cerebral cortex.The Journal of physiology · 2011Article
- The depolarizing action of GABA controls early network activity in the developing hippocampus.Molecular neurobiology · 2011Review
- Amygdalocortical circuitry in schizophrenia: from circuits to molecules.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Review
- Temporal coding at the immature depolarizing GABAergic synapse.Frontiers in cellular neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of synaptic connections and their refinement during development require neural activity. Increasing evidence suggests that spontaneous bursts of neural activity within an immature network are mediated by gamma-aminobutyric acid via a paradoxical excitatory action. Our data show that in the developing hippocampus such synchronous burst activity is generated in the hilar region by transiently coupled cells. These cells have been identified as neuronal elements because they fire action potentials and they are not positive for the glial fibrillary acidic protein staining. Oscillations in hilar cells are "paced" by a hyperpolarization-activated current, with properties of Ih. Coactivated interneurons synchronously release GABA, which via its excitatory action may serve a neurotrophic function during the refinement of hippocampal circuitry.
Indexed as
Identifiers
9006985PMC6793743What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.