ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 89 citations in OpenAlex.
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- Astrocytes, neurons, synapses: a tripartite view on cortical circuit development.Neural development · 2018Review
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- Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells.Cell transplantation · 2017Article
- Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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- Pattern formation during development of the embryonic cerebellum.Frontiers in neuroanatomy · 2012Article
- Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Synaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosis.Neurochemical research · 2011Review
- Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.The Journal of biological chemistry · 2010Article
- Functional polarity in neurons: what can we learn from studying an exception?Current opinion in neurobiology · 2010Review
- Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses.The Journal of comparative neurology · 2010Article
- Developmental alterations in the functional properties of excitatory neocortical synapses.The Journal of physiology · 2009Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptotagmin I is an abundant synaptic vesicle protein that has an essential function in mediating Ca2+-triggered neurotransmitter release. We have analyzed the distribution of four neural synaptotagmin isoforms during postnatal development of the rat CNS by in situ hybridization. Synaptotagmin I, II, III, and IV genes have distinct patterns of spatiotemporal expression except in cerebellum granule cells, where the four transcripts were detected during the formation of parallel fiber/Purkinje cell synapses. Throughout development synaptotagmin I mRNAs were widely expressed in brain, whereas synaptotagmin II transcripts were predominant in spinal cord. At all stages synaptotagmin III mRNAs were expressed uniformly in most neurons examined, although at a low level. Synaptotagmin I, II, and III gene expressions mainly increased during development and persisted in adulthood, mirroring neuronal differentiation. Conversely, synaptotagmin IV transcripts were predominant during perinatal development in a heterogeneous population of neurons and subsequently were expressed uniformly at a low level. Intense labeling was observed in the hippocampal CA3 field and in the subiculum, but not in the CA1 field, of the newborn rat. In cerebral cortex, lamina-specific labeling was detected with a high expression in cell layer V. Only a small number of Purkinje cell clusters were labeled in the flocculus and paraflocculus of the cerebellum. Heterogeneous sets of neurons expressing synaptotagmin IV gene also were observed in spinal cord. We thus speculate that synaptotagmin IV may a play a role in the development of the mammalian nervous system.
Indexed as
Identifiers
9006966PMC6793732W1947397418What OpenQuestion holds
Registered trials
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