ArticleThe American journal of pathology1997
Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 72 citations in OpenAlex.
- Pediatric cerebral cavernous malformations: Genetics, pathogenesis, and management.Surgical neurology international · 2016Review
- Immunohistochemical detection of receptor-associated protein in normal human brain and Alzheimer's disease.Pathology research international · 2010Article
- Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway.Cell cycle (Georgetown, Tex.) · 2009Review
- Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis.The American journal of pathology · 2002Article
- Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat.Environmental health perspectives · 2001Article
- Article
- Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes.The EMBO journal · 2000Article
- Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis.Brain pathology (Zurich, Switzerland) · 1999Article
- Autism and tuberous sclerosis.Journal of autism and developmental disorders · 1998Review
- The development of the kidney.Current topics in developmental biology · 1998Review
- Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors.The American journal of pathology · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tuberous sclerosis-2 (TSC2) gene is linked to tuberous sclerosis (TSC), a dominantly inherited genetic syndrome in which inactivation of the normal TSC2 allele is associated with the development of mostly benign tumors and focal dysplasias. TSC2 encodes the protein tuberin, which is a widely expressed 180-kd polypeptide that exhibits specific GTPase activating activity toward Rap1 in vitro and co-localizes with Rap1 in cultured cells. In this study, we have performed immunohistochemical analyses, using affinity-purified anti-tuberin antibodies, to study the distribution of tuberin in a panel of normal human organs that are commonly affected by TSC. Cryosections indicated that tuberin is widely expressed at low levels. More intense staining of tuberin, in the cryosections and in paraffin sections, was observed in the small blood vessels of many organs, including the kidney, skin, and adrenal gland. High levels of tuberin were also detected in cortical neurons and cerebellar Purkinje cells. These findings imply that loss-of-function mutations in TSC2 might lead to the development of highly vascularized tumors, subcortical tubers, and focal atrophy of the cerebellar cortex, which are features commonly associated with TSC. Moreover, Rap1 was also found to be highly expressed in many of the same cells that contained high levels of tuberin, suggesting a functional interaction between tuberin and Rap1 in these tissues.
Indexed as
Identifiers
9006320PMC1858502W1836797866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.