ArticleThe Journal of clinical investigation1997
Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
- Lipoprotein-dependent and -independent immune responses to spirochetal infection.Clinical and diagnostic laboratory immunology · 2005Trial
- Observational
- Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy.Memorias do Instituto Oswaldo Cruz · 2017Article
- Characterization of a caprine model for the subclinical initial phase of Mycobacterium avium subsp. paratuberculosis infection.BMC veterinary research · 2015Article
- Galectin-3 regulates the innate immune response of human monocytes.The Journal of infectious diseases · 2013Article
- The Th1:th2 dichotomy of pregnancy and preterm labour.Mediators of inflammation · 2012Review
- Synergistic enhancement of cellular immune responses by the novel Toll receptor 7/8 agonist 3M-007 and interferon-γ: implications for therapy of cutaneous T-cell lymphoma.Leukemia & lymphoma · 2011Article
- A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy.Immunology · 2010Article
- AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2008Article
- Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.The Journal of biological chemistry · 2008Article
- Differential cytokine gene expression profiles in the three pathological forms of sheep paratuberculosis.BMC veterinary research · 2007Article
- Cytokine production and lymphocyte proliferation in patients with Nocardia brasiliensis actinomycetoma.Mycopathologia · 2004Article
- Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation.Immunology · 2004Article
- Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia burgdorferi lipoproteins.Infection and immunity · 2002Article
- Review
- New age adjuvants and delivery systems for subunit vaccines.Indian journal of clinical biochemistry : IJCB · 2000Article
- Th1/Th2 balance in infection.Springer seminars in immunopathology · 1999Review
- Human Th1 responses driven by IL-12 are associated with enhanced expression of CD40 ligand.Clinical and experimental immunology · 1999Article
- Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD.Clinical and experimental immunology · 1998Article
- Interleukin-12 in infectious diseases.Clinical microbiology reviews · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The ability of monocytes to influence the nature of the T cell response to microbial pathogens is mediated in part by the release of cytokines. Of particular importance is the release of IL-12 and IL-10 by cells of the monocyte/macrophage lineage upon encountering the infectious agent. IL-12 promotes cell mediated immunity (CMI) to intracellular pathogens by augmenting T-helper type 1 responses, whereas IL-10 downregulates these responses. The ability of IFN-gamma to modulate the balance between IL-12 and IL-10 production was examined by studying leprosy as a model. In response to Mycobacterium leprae stimulation, IFN-gamma differentially regulated IL-12 and IL-10 production resulting in upregulation of IL-12 release and downregulation of IL-10 release. Furthermore, we determined that the mechanism by which IFN-gamma downregulates IL-10 was through the induction of IL-12. The data suggest a model of lymphocyte-monocyte interaction whereby the relative presence or absence of IFN-gamma in the local microenvironment is a key determinant of the type of monocyte cytokine response, and hence the degree of CMI in the host response to infection.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.