ArticleThe Journal of physiology1996
cGMP-mediated effects on the physiology of bovine and human retinal Müller (glial) cells.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 53 citations in OpenAlex.
- cGMP Signaling in the Neurovascular Unit-Implications for Retinal Ganglion Cell Survival in Glaucoma.Biomolecules · 2022Review
- New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels.Pflugers Archiv : European journal of physiology · 2014Review
- Role of cyclic nucleotide-gated channels in the modulation of mouse hippocampal neurogenesis.PloS one · 2013Article
- Modulation by brain natriuretic peptide of GABA receptors on rat retinal ON-type bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Soluble guanylate cyclases in the retina.Molecular and cellular biochemistry · 2002Review
- Calcium-modulated membrane guanylate cyclase in synaptic transmission?Molecular and cellular biochemistry · 2002Review
- Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Ultracytochemical study of guanylate cyclases A and B in light- and dark-adapted retinas.The Histochemical journal · 1999Article
- Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Serum-induced changes in the physiology of mammalian retinal glial cells: role of lysophosphatidic acid.The Journal of physiology · 1998Article
- Intracellular ATP activates inwardly rectifying K+ channels in human and monkey retinal Müller (glial) cells.The Journal of physiology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. Whole-cell currents of freshly dissociated or cultured Müller cells from human and bovine retinas were studied using the perforated-patch and standard whole-cell recording techniques. 2. We found that internal perfusion of cGMP or external exposure to 8-bromo-cGMP activated a calcium permeable, non-selective cation current in Müller cells, the principal glial cells of the retina. In addition, the activity of calcium-activated potassium channels increased markedly. These currents were minimally affected by cAMP. 3. Molecular studies using the reverse transcription-polymerase chain reaction demonstrated that human müller cells in culture contain transcripts closely related to the rod cyclic nucleotide-gated (CNG) channel. 4. Since guanylate cyclase is a known target for nitric oxide (NO), we tested the effect of NO donors on Müller cell currents. These agents induced currents that were qualitatively similar to those activated by cGMP. 5. Our experiments support the idea that the NO-cGMP pathway regulates the physiology of Müller cells and may play a role in integrating neuron-glia interactions in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.