ArticleThe Biochemical journal1997
Glucose induces the translocation of glycogen synthase to the cell cortex in rat hepatocytes.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 78 citations in OpenAlex.
- Cross-linked actin networks (CLANs) affect stiffness and/or actin dynamics in transgenic transformed and primary human trabecular meshwork cells.Experimental eye research · 2022Article
- Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling.iScience · 2021Article
- The dynamic life of the glycogen granule.The Journal of biological chemistry · 2018Review
- Biological characterization of a novel hybrid copolymer carrier system based on glycogen.Drug delivery and translational research · 2018Article
- HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data.PLoS computational biology · 2016Article
- Neuronal glycogen synthesis contributes to physiological aging.Aging cell · 2014Article
- The 3T3-L1 adipocyte glycogen proteome.Proteome science · 2013Article
- Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.The Journal of biological chemistry · 2010Article
- Regulation of glycogen metabolism in yeast and bacteria.FEMS microbiology reviews · 2010Review
- The subcellular localization of yeast glycogen synthase is dependent upon glycogen content.Canadian journal of microbiology · 2010Article
- Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization.The Journal of biological chemistry · 2009Article
- "Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection.Glycoconjugate journal · 2008Article
- Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.The Biochemical journal · 2004Article
- Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes.The Biochemical journal · 2001Article
- Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes.The Biochemical journal · 2001Article
- Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content.The Journal of physiology · 2001Article
- Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase.The Biochemical journal · 2000Article
- Specific features of glycogen metabolism in the liver.The Biochemical journal · 1998Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After incubation with glucose a dramatic change in the intracellular distribution of glycogen synthase was observed in rat hepatocytes. Confocal laser scanning microscopy showed that glycogen synthase existed diffusely in the cytosol of control cells, whereas in cells incubated with glucose it accumulated at the cell periphery. Colocalization analysis between glycogen synthase immunostaining and actin filaments showed that the change in glycogen synthase distribution induced by glucose correlated with a marked increase in the co-distribution of the two proteins, indicating that, in response to glucose, glycogen synthase moves to the actin-rich area close to the membrane. When glycogen synthase was immunostained with rabbit anti-(glycogen synthase) and Protein A-colloidal gold, few particles were observed close to the membrane in control cells. In contrast, in cells incubated with glucose most of the gold particles were found near the membrane, confirming that glycogen synthase had moved to the cell cortex. Furthermore, in agreement with the glycogen synthase distribution, glycogen deposition appeared to be more active at the periphery of the cell.
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