ArticleBulletin of the World Health Organization1996
Standard management of acute respiratory infections in a children's hospital in Pakistan: impact on antibiotic use and case fatality.
Article in Bulletin of the World Health Organization, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The effect of case management on childhood pneumonia mortality in developing countries.International journal of epidemiology · 2010Pooled it
- Integrated management of childhood illness by outpatient health workers: technical basis and overview. The WHO Working Group on Guidelines for Integrated Management of the Sick Child.Bulletin of the World Health Organization · 1997Guideline
- Community case management of fast-breathing pneumonia with 3 days oral amoxicillin vs 5 days cotrimoxazole in children 2-59 months of age in rural Pakistan: A cluster randomized trial.Journal of global health · 2022Trial
- Innovative, enhanced community management of non-hypoxaemic chest-indrawing pneumonia in 2-59-month-old children: a cluster-randomised trial in Africa and Asia.BMJ global health · 2022Trial
- Community-based amoxicillin treatment for fast breathing pneumonia in young infants 7-59 days old: a cluster randomised trial in rural Bangladesh, Ethiopia, India and Malawi.BMJ global health · 2021Trial
- Comparison of 3 Days Amoxicillin Versus 5 Days Co-Trimoxazole for Treatment of Fast-breathing Pneumonia by Community Health Workers in Children Aged 2-59 Months in Pakistan: A Cluster-randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Trial
- Community case management of severe pneumonia with oral amoxicillin in children aged 2-59 months in Haripur district, Pakistan: a cluster randomised trial.Lancet (London, England) · 2011Trial
- Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study).BMJ (Clinical research ed.) · 2008Trial
- Implementation research on enhanced community case management of pneumonia in Bangladesh: study protocol.Journal of global health · 2026Article
- Management and outcomes of chest-indrawing pneumonia among children aged 2-59 months in a programme setting in Ethiopia: a prospective observational study.Journal of global health · 2025Observational
- Outcomes of children aged 2-59 months with chest indrawing pneumonia managed on an outpatient basis in selected primary health facilities in Zambia.Journal of global health · 2025Article
- Outcome and management of children with chest indrawing pneumonia at primary health care settings in Pakistan: an observational cohort study.Journal of global health · 2025Observational
- Effects of Training Health Workers in Integrated Management of Childhood Illness on Quality of Care for Under-5 Children in Primary Healthcare Facilities in Afghanistan.International journal of health policy and management · 2020Article
- Environmental enteric dysfunction: a review of potential mechanisms, consequences and management strategies.BMC medicine · 2019Review
- Effect of community mobilization on appropriate care seeking for pneumonia in Haripur, Pakistan.Journal of global health · 2015Article
- Clinical Effectiveness of Co-trimoxazole vs. Amoxicillin in the Treatment of Non-Severe Pneumonia in Children in India: A Randomized Controlled Trial.International journal of preventive medicine · 2013Article
- Frequency and trajectory of abnormalities in respiratory rate, temperature and oxygen saturation in severe pneumonia in children.The Pediatric infectious disease journal · 2012Article
- Outpatient treatment of children with severe pneumonia with oral amoxicillin in four countries: the MASS study.Tropical medicine & international health : TM & IH · 2011Article
- Comparative impact assessment of child pneumonia interventions.Bulletin of the World Health Organization · 2009Article
- Challenges to improving case management of childhood pneumonia at health facilities in resource-limited settings.Bulletin of the World Health Organization · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute respiratory infections (ARI) are a leading cause of childhood morbidity and mortality in Pakistan. The National ARI Control Programme was launched in 1989 in order to reduce the mortality attributed to pneumonia, and rationalize the use of drugs in the management of patients with ARI. WHO's standard ARI case management guidelines were adopted to achieve these objectives. The medical staff at the Children's Hospital, Islamabad, were trained in such management in early 1990; further training sessions were conducted when new staff arrived. Data on outpatients were obtained from special ARI abstract registers, which have been maintained in the outpatient department since January 1990. Details on inpatients who were admitted with ARI were obtained from hospital registers. During the period 1989-92, the use of antibiotics in the outpatient department decreased from 54.6% to 22.9% (P < 0.0001). The case fatality rate (CFR) in children admitted with ARI fell from 9.9% to 4.9% (P < 0.0001), while the overall case fatality rate fell from 8.7% to 6.2%. Our results from a tertiary health care facility show that standard ARI case management reduced both antibiotic use and expenditure on drugs. Although the ARI case management criteria, which are more sensitive than the conventional diagnostic criteria of auscultation and radiography, led to more admissions, we believe that this strategy contributed to a significant reduction in the ARI case fatality rate.
Indexed as
Identifiers
9002330PMC2486861W1640350970What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.