ArticleMolecular and cellular biology1997
Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Dynamic alternative DNA structures in biology and disease.Nature reviews. Genetics · 2023Review
- The inner side of yeast PCNA contributes to genome stability by mediating interactions with Rad18 and the replicative DNA polymerase δ.Scientific reports · 2022Article
- Protein innovation through template switching in the Saccharomyces cerevisiae lineage.Scientific reports · 2021Article
- Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability.DNA repair · 2014Review
- Models for chromosomal replication-independent non-B DNA structure-induced genetic instability.Molecular carcinogenesis · 2009Review
- Article
- Palindrome-mediated chromosomal translocations in humans.DNA repair · 2006Review
- DNA replication origin plasticity and perturbed fork progression in human inverted repeats.Molecular and cellular biology · 2005Article
- Article
- Characterization of the hyperrecombination phenotype of the pol3-t mutation of Saccharomyces cerevisiae.Genetics · 2003Article
- In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta.Genetics · 2001Article
- Article
- Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.Genetics · 1999Article
- The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae.Molecular and cellular biology · 1999Article
- Article
- Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).Molecular and cellular biology · 1998Article
- Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiae.Genetics · 1998Article
- Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Molecular and cellular biology · 1997Article
- The yin and yang of repair mechanisms in DNA structure-induced genetic instability.Mutation researchReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Replication, DNA organization, and mismatch repair (MMR) can influence recombination. We examined the effects of altered replication due to a mutation in the polymerase delta gene, long inverted repeats (LIRs) in motifs similar to those in higher eukaryotes, and MMR on intrachromosomal recombination between highly diverged (28%) truncated genes in Saccharomyces cerevisiae. A combination of altered replication and an LIR increased recombination up to 700-fold, while each alone led to a 3- to 20-fold increase. Homeologous recombination was not altered by pms1, msh2, and msh3 mismatch repair mutations. Similar to our previous observations for replication slippage-mediated deletions, there were > or = 5-bp identical runs at the recombination breakpoints. We propose that the dramatic increase in recombination results from enhancement of the effects of altered replication by the LIR, leading to recombinationally active initiating structures. Such interactions predict replication-related, MMR-independent genome changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.