ArticleMolecular and cellular biology1997
Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- ID1 and CEBPA coordinate epidermal progenitor cell differentiation.Development (Cambridge, England) · 2022Article
- Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior.Cell and tissue research · 2022Review
- CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3.Scientific reports · 2018Article
- Id1 has a physiological role in regulating early B lymphopoiesis.Cellular & molecular immunology · 2011Article
- Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation.The Journal of biological chemistry · 2009Article
- Article
- Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1.BMC immunology · 2005Article
- Contingent gene regulatory networks and B cell fate specification.Proceedings of the National Academy of Sciences of the United States of America · 2005Review
- Regulation of Id2 expression by CCAAT/enhancer binding protein beta.Nucleic acids research · 2005Article
- STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.The EMBO journal · 2003Article
- Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter.Molecular and cellular biology · 2002Article
- Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.Molecular and cellular biology · 2001Article
- Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Id1 protein acts as a negative regulator in early-B-cell differentiation by antagonizing the function of the basic helix-loop-helix transcription factors. Expression of the Id1 gene during B-cell development is governed at the transcriptional level primarily by a pro-B-cell-specific enhancer (PBE) located 3 kb downstream of the gene. We report here the identification of CAAT/enhancer binding protein beta (C/EBPbeta) as a component of the two major PBE-binding complexes (PBEC1 and PBEC2) found in pro-B cells by gel mobility shift assays. Formation of the PBECs is abolished when a classic C/EBP binding site is used as a competitor, and binding complexes similar to the PBECs are formed when the classic C/EBP site is used as a probe. We show that CHOP, a negative regulator of C/EBPs, specifically inhibits PBE binding in vitro and its enhancer activity in vivo. In pro-B cells, C/EBPbeta binds to the PBE site not as apparent homodimers but possibly in association with at least one other polypeptide, which might determine the pro-B-cell-specific expression of the Id1 gene. Although isoforms of C/EBPbeta are expressed in various B cells, they bind to DNA only in LyD9 and Ba/F3 pro-B cells. We show that CHOP is expressed in 70Z/3 and WEHI-231 cells. We also demonstrate that CHOP is associated with C/EBPbeta in WEHI-231 cells, which may provide an additional mechanism to control the function of C/EBPbeta and the expression of the Id1 gene.
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