ArticleMolecular and cellular biology1997
Multiple phosphorylated forms of the Saccharomyces cerevisiae Mcm1 protein include an isoform induced in response to high salt concentrations.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
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- Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata.Journal of biomedical science · 2021Article
- Genome-Wide Diversity of MADS-Box Genes in Bread Wheat is Associated with its Rapid Global Adaptability.Frontiers in genetics · 2021Article
- A mitogen-activated protein kinase PoxMK1 mediates regulation of the production of plant-biomass-degrading enzymes, vegetative growth, and pigment biosynthesis in Penicillium oxalicum.Applied microbiology and biotechnology · 2021Article
- Identification and expression analysis of conserved microRNAs during short and prolonged chromium stress in rice (Oryza sativa).Environmental science and pollution research international · 2020Article
- Conservation and diversity of the regulators of cellulolytic enzyme genes in Ascomycete fungi.Current genetics · 2017Review
- Genome-wide identification and analysis of the MADS-box gene family in bread wheat (Triticum aestivum L.).PloS one · 2017Article
- Identification of miRNAs in sorghum by using bioinformatics approach.Plant signaling & behavior · 2012Article
- Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa).Journal of experimental botany · 2011Article
- Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site.Eukaryotic cell · 2006Article
- N-terminal arm of Mcm1 is required for transcription of a subset of genes involved in maintenance of the cell wall.Eukaryotic cell · 2005Article
- Alpha1-induced DNA bending is required for transcriptional activation by the Mcm1-alpha1 complex.Nucleic acids research · 2004Article
- The essential transcription factor Reb1p interacts with the CLB2 UAS outside of the G2/M control region.Nucleic acids research · 2003Article
- Swapping functional specificity of a MADS box protein: residues required for Arg80 regulation of arginine metabolism.Molecular and cellular biology · 2002Article
- Interactions of the Mcm1 MADS box protein with cofactors that regulate mating in yeast.Molecular and cellular biology · 2002Article
- Characterization of the ECB binding complex responsible for the M/G(1)-specific transcription of CLN3 and SWI4.Molecular and cellular biology · 2002Article
- A catalytic subunit of the sugar beet protein kinase CK2 is induced by salt stress and increases NaCl tolerance in Saccharomyces cerevisiae.Plant molecular biology · 2001Article
- Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation.Genes & development · 2001Article
- The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF.The EMBO journal · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Saccharomyces cerevisiae Mcm1 protein is an essential multifunctional transcription factor which is highly homologous to human serum response factor. Mcm1 protein acts on a large number of distinctly regulated genes: haploid cell-type-specific genes, G2-cell-cycle-regulated genes, pheromone-induced genes, arginine metabolic genes, and genes important for cell wall and cell membrane function. We show here that Mcm1 protein is phosphorylated in vivo. Several (more than eight) isoforms of Mcm1 protein, resolved by isoelectric focusing, are present in vivo; two major phosphorylation sites lie in the N-terminal 17 amino acids immediately adjacent to the conserved MADS box DNA-binding domain. The implications of multiple species of Mcm1, particularly the notion that a unique Mcm1 isoform could be required for regulation of a specific set of Mcm1's target genes, are discussed. We also show here that Mcm1 plays an important role in the response to stress caused by NaCl. G. Yu, R. J. Deschenes, and J. S. Fassler (J. Biol. Chem. 270:8739-8743, 1995) showed that Mcm1 function is affected by mutations in the SLN1 gene, a signal transduction component implicated in the response to osmotic stress. We find that mcm1 mutations can confer either reduced or enhanced survival on high-salt medium; deletion of the N terminus or mutation in the primary phosphorylation site results in impaired growth on high-salt medium. Furthermore, Mcm1 protein is a target of a signal transduction system responsive to osmotic stress: a new isoform of Mcm1 is induced by NaCl or KCl; this result establishes that Mcm1 itself is regulated.
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