ArticleMolecular and cellular biology1997
Evidence for the involvement of mouse heat shock factor 1 in the atypical expression of the HSP70.1 heat shock gene during mouse zygotic genome activation.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Transcription Factor TCF12-Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation.Cell proliferation · 2026Article
- TPST2-mediated tyrosine sulfation orchestrates porcine preimplantation development.BMC biology · 2026Article
- A long noncoding RNA with enhancer-like function in pig zygotic genome activation.Journal of molecular cell biology · 2025Article
- Maternal effect factors that contribute to oocytes developmental competence: an update.Journal of assisted reproduction and genetics · 2022Review
- Differential correlations between changes to glutathione redox state, protein ubiquitination, and stress-inducible HSPA chaperone expression after different types of oxidative stress.Cell stress & chaperones · 2018Article
- Article
- Basal and stress-induced Hsp70 are modulated by ataxin-3.Cell stress & chaperones · 2012Article
- Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.Molecular and cellular biology · 2011Article
- HSFs and regulation of Hsp70.1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models.Cell stress & chaperones · 2011Article
- Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.PloS one · 2011Article
- Molecular Characterization of Heat Shock Protein 70-1 Gene of Goat (Capra hircus).Molecular biology international · 2010Article
- Effects of heat stress on mammalian reproduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- RNA polymerase II interacts with the Hspa1b promoter in mouse epididymal spermatozoa.Reproduction (Cambridge, England) · 2009Article
- Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa.Biology of reproduction · 2008Article
- Early onset of heat-shock response in mouse embryos revealed by quantification of stress-inducible hsp70i RNA.Gene regulation and systems biology · 2007Article
- HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.Genes & development · 2007Article
- Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.Genes & development · 2006Article
- Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.Molecular and cellular biology · 2002Article
- Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice.The EMBO journal · 2002Article
- Function and regulation of heat shock factor 2 during mouse embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse HSP70.1 gene, which codes for a heat shock protein (hsp70), is highly transcribed at the onset of zygotic genome activation (ZGA). This expression, which occurs in the absence of stress, is then repressed. It has been claimed that this gene does not exhibit a stress response until the blastocyst stage. The promoter of HSP70.1 contains four heat shock element (HSE) boxes which are the binding sites of heat shock transcription factors (HSF). We have been studying the presence and localization of the mouse HSFs, mHSF1 and mHSF2, at different stages of embryo development. We show that mHSF1 is already present at the one-cell stage and concentrated in the nucleus. Moreover, by mutagenizing HSE sequences and performing competition experiments (in transgenic embryos with the HSP70.1 promoter inserted before a reporter gene), we show that, in contrast with previous findings, HSE boxes are involved in this spontaneous activation. Therefore, we suggest that HSF1 and HSE are important in this transient expression at the two-cell stage and that the absence of typical inducibility at this early stage of development results mainly from the high level of spontaneous transcription of this gene during the ZGA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.