ArticleMolecular and cellular biology1997
Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 92 citations in OpenAlex.
- Breast cancer animal models and applications.Zoological research · 2020Review
- Molecular interactions in juvenile nasopharyngeal angiofibroma: preliminary signature and relevant review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Review
- The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy.Oncotarget · 2016Article
- Genome Stability Requires p53.Cold Spring Harbor perspectives in medicine · 2016Review
- DNA damage and the balance between survival and death in cancer biology.Nature reviews. Cancer · 2016Review
- Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma.OncoTargets and therapy · 2016Review
- Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells.Marine drugs · 2015Article
- Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.PloS one · 2015Article
- Genetically engineered mice as experimental tools to dissect the critical events in breast cancer.Advances in cancer research · 2014Review
- Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.Disease models & mechanisms · 2012Article
- Trp53 regulates Notch 4 signaling through Mdm2.Journal of cell science · 2011Article
- p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest.Molecular cancer therapeutics · 2011Article
- The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.Oncogene · 2010Article
- Influence of Hoxa5 on p53 tumorigenic outcome in mice.The American journal of pathology · 2010Article
- MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer.Expert review of molecular diagnostics · 2009Review
- Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis.Molecular cancer · 2009Article
- Loss of cryptochrome reduces cancer risk in p53 mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- p21 delays tumor onset by preservation of chromosomal stability.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells.Oncogene · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have used an in vivo tumor model to evaluate the consequences of p53 tumor suppressor protein deficiency in a tissue-specific context. By breeding MMTV-ras transgenic mice, which are highly susceptible to the development of mammary and salivary tumors, with p53(-/-) mice, we generated three classes of animals which contained the MMTV-ras transgene but differed in their p53 functional status (ras/p53(+/+), ras/p53(+/-), or ras/p53(-/-)). ras/p53(-/-) mice developed tumors more rapidly than animals of the other two genotypes; however, the distribution of tumors was unexpectedly altered. Whereas the most frequently observed tumors in ras/p53(+/+) and ras/p53(+/-) mice were of mammary origin, ras/p53(-/-) mice developed primarily salivary tumors. In addition, the mammary and salivary tumors from ras/p53(-/-) mice consistently exhibited a number of unfavorable characteristics, including higher histologic grades, increased growth rates, and extensive genomic instability and heterogeneity, relative to tumors from ras/p53(+/+) mice. Interestingly, the increased growth rates of ras/p53(-/-) tumors appear to be due to impaired cell cycle regulation rather than decreased apoptosis, suggesting that p53-mediated tumor suppression can occur independent of its role in apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.