ArticleMolecular and cellular biology1997
A combination of MEF3 and NFI proteins activates transcription in a subset of fast-twitch muscles.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells.EMBO molecular medicine · 2024Article
- Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration.Nature communications · 2017Article
- MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.Nucleic acids research · 2016Article
- Nfix Regulates Temporal Progression of Muscle Regeneration through Modulation of Myostatin Expression.Cell reports · 2016Article
- Overexpression of Six1 gene suppresses proliferation and enhances expression of fast-type muscle genes in C2C12 myoblasts.Molecular and cellular biochemistry · 2013Article
- Discovery, optimization and validation of an optimal DNA-binding sequence for the Six1 homeodomain transcription factor.Nucleic acids research · 2012Article
- Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis.Development (Cambridge, England) · 2012Article
- Article
- Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer.Skeletal muscle · 2011Article
- GSMA: Gene Set Matrix Analysis, An Automated Method for Rapid Hypothesis Testing of Gene Expression Data.Bioinformatics and biology insights · 2009Article
- Nuclear factor I X deficiency causes brain malformation and severe skeletal defects.Molecular and cellular biology · 2007Article
- nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival.BMC developmental biology · 2005Article
- Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype.Molecular and cellular biology · 2004Article
- Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.Molecular and cellular biology · 2004Article
- Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription.Molecular and cellular biology · 2001Article
- Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway.The EMBO journal · 2001Article
- Functional analysis of the homeodomain protein SIX5.Nucleic acids research · 2000Article
- Expression, DNA-binding specificity and transcriptional regulation of nuclear factor 1 family proteins from rat.The Biochemical journal · 1999Article
- Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements.Molecular and cellular biology · 1999Article
- Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human aldolase A pM promoter is active in fast-twitch muscles. To understand the role of the different transcription factors which bind to this promoter and determine which ones are responsible for its restricted pattern of expression, we analyzed several transgenic lines harboring different combinations of pM regulatory elements. We show that muscle-specific expression can be achieved without any binding sites for the myogenic factors MyoD and MEF2 and that a 64-bp fragment comprising a MEF3 motif and an NFI binding site is sufficient to drive reporter gene expression in some but, interestingly, not all fast-twitch muscles. A result related to this pattern of expression is that some isoforms of NFI proteins accumulate differentially in fast- and slow-twitch muscles and in distinct fast-twitch muscles. We propose that these isoforms of NFI proteins might provide a molecular basis for skeletal muscle diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.