ArticleMammalian genome : official journal of the International Mammalian Genome Society1996
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Positional cloning of rat mutant genes reveals new functions of these genes.Experimental animals · 2023Review
- Inherited and acquired disorders of myelin: The underlying myelin pathology.Experimental neurology · 2016Review
- Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.PloS one · 2016Article
- A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.PLoS genetics · 2011Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
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Abstract
A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.
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