ArticleJournal of molecular evolution1996
Determinants of rate variation in mammalian DNA sequence evolution.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Multiple drivers of genomic novelty across ruminants.iScience · 2026Article
- Gene-Specific Substitution Rates for the Vespertilionidae (Chiroptera: Mammalia) Mitochondrial Genome, with the Description of Three new Mitogenomes.Journal of molecular evolution · 2025Article
- Influence of life-history traits on mitochondrial DNA substitution rates exceeds that of metabolic rates in teleost fishes.Current zoology · 2025Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Estimates of the Mutation Rate per Year Can Explain Why the Molecular Clock Depends on Generation Time.Molecular biology and evolution · 2025Article
- Genome-wide analysis reveals the contributors to fast molecular evolution of the Chinese hook snout carp (Computational and structural biotechnology journal · 2024Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.bioRxiv : the preprint server for biology · 2024Article
- Gene Protein Sequence Evolution Can Predict the Rapid Divergence of Ovariole Numbers in the Drosophila melanogaster Subgroup.Genome biology and evolution · 2024Article
- Temperature-Dependent Evolutionary Speed Shapes the Evolution of Biodiversity Patterns Across Tetrapod Radiations.Systematic biology · 2023Article
- Body size predicts the rate of contemporary morphological change in birds.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Novel genome sequence of Chinese cavefish (Triplophysa rosa) reveals pervasive relaxation of natural selection in cavefish genomes.Molecular ecology · 2022Article
- Environmental niche and flight intensity are associated with molecular evolutionary rates in a large avian radiation.BMC ecology and evolution · 2022Article
- Signatures of Adaptation in Mitochondrial Genomes of Palearctic Subterranean Voles (Arvicolinae, Rodentia).Genes · 2021Article
- Life-history traits and habitat availability shape genomic diversity in birds: implications for conservation.Proceedings. Biological sciences · 2021Article
- Searching for signatures of positive selection in cytochrome b gene associated with subterranean lifestyle in fast-evolving arvicolines (Arvicolinae, Cricetidae, Rodentia).BMC ecology and evolution · 2021Article
- Article
- The Dynamics, Causes, and Impacts of Mammalian Evolutionary Rates Revealed by the Analyses of Capybara Draft Genome Sequences.Genome biology and evolution · 2020Article
- The Implications of Lineage-Specific Rates for Divergence Time Estimation.Systematic biology · 2020Article
- Flanking heterozygosity influences the relative probability of different base substitutions in humans.Royal Society open science · 2019Article
- Evolutionary Rates of Bumblebee Genomes Are Faster at Lower Elevations.Molecular biology and evolution · 2019Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Attempts to analyze variation in the rates of molecular evolution among mammalian lineages have been hampered by paucity of data and by nonindependent comparisons. Using phylogenetically independent comparisons, we test three explanations for rate variation which predict correlations between rate variation and generation time, metabolic rate, and body size. Mitochondrial and nuclear genes, protein coding, rRNA, and nontranslated sequences from 61 mammal species representing 14 orders are used to compare the relative rates of sequence evolution. Correlation analyses performed on differences in genetic distance since common origin of each pair against differences in body mass, generation time, and metabolic rate reveal that substitution rate at fourfold degenerate sites in two out of three protein sequences is negatively correlated with generation time. In addition, there is a relationship between the rate of molecular evolution and body size for two nuclear-encoded sequences. No evidence is found for an effect of metabolic rate on rate of sequence evolution. Possible causes of variation in substitution rate between species are discussed.
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