ArticleClinical and diagnostic laboratory immunology1996
T-cell proliferative response to human papillomavirus type 16 peptides: relationship to cervical intraepithelial neoplasia.
Article in Clinical and diagnostic laboratory immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Trial
- A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence.medRxiv : the preprint server for health sciences · 2026Article
- Depletion of Human Papilloma Virus E6- and E7-Oncoprotein-Specific T-Cell Responses in Women Living With HIV.Frontiers in immunology · 2021Article
- Classical HLA alleles are associated with prevalent and persistent cervical high-risk HPV infection in African women.Human immunology · 2019Article
- Article
- Overcoming Barriers to Cervical Cancer Screening Among Asian American Women.North American journal of medicine & science · 2011Article
- Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia: First-in-Human, Proof-of-Concept Trial.ISRN obstetrics and gynecology · 2011Article
- Progesterone and 17beta-estradiol enhance regulatory responses to human papillomavirus type 16 virus-like particles in peripheral blood mononuclear cells from healthy women.Clinical and vaccine immunology : CVI · 2010Article
- Human papillomavirus 16-specific T cell responses in classic HPV-related vulvar intra-epithelial neoplasia. Determination of strongly immunogenic regions from E6 and E7 proteins.Clinical and experimental immunology · 2010Article
- HPV Vaccines: today and in the Future.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2008Review
- The future of vaccines for cervical cancer.Gynecologic oncology · 2008Article
- Perceived stress is associated with impaired T-cell response to HPV16 in women with cervical dysplasia.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2008Article
- Recent advances in strategies for immunotherapy of human papillomavirus-induced lesions.International journal of cancer · 2008Review
- T-cell responses to human papillomavirus type 16 among women with different grades of cervical neoplasia.British journal of cancer · 2005Article
- Time course of humoral and cell-mediated immune responses to human papillomavirus type 16 in infected women.Clinical and diagnostic laboratory immunology · 2002Article
- Cell-mediated immune response to human papillomavirus infection.Clinical and diagnostic laboratory immunology · 2001Review
- Co-infection of syphilis and hepatitis B with carcinoma penis in a human immunodeficiency virus male.Indian journal of sexually transmitted diseases and AIDSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The incidence of human papillomavirus (HPV)-related cervical intraepithelial neoplasia (CIN) and cervical cancer is increased with immunodeficiency, but the role of immune response, including cell-mediated immunity, in disease prevention is not well understood. In this study, T-cell proliferative responses to six synthetic peptides with predicted immunogenic determinants from the HPV-16 E4, E6, E7, and L1 open reading frames were analyzed in 22 sexually active women with new-onset CIN and 65 sexually active women without cervical disease, characterized by cytology, colposcopy, and HPV testing. T-cell proliferative responses were demonstrated to all six HPV-16 peptides. Although not statistically significant, rates of reactivity to E6 (24-45) were higher among sexually active women without disease (26%) than among women with current CIN (7%), as was the overall number of peptides stimulating a response. Women with CIN may not respond to selected HPV antigens as well as women without disease do.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.