ArticleThe Journal of cell biology1996
Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition.Frontiers in cell and developmental biology · 2025Review
- The light chain of tetanus toxin bound to arginine-rich cell-penetrating peptide inhibits cortical reaction in mouse oocytes.Frontiers in cell and developmental biology · 2023Article
- VAMPs sensitive to tetanus toxin are required for cortical granule exocytosis in mouse oocytes.Experimental cell research · 2021Article
- Knockin' on Egg's Door: Maternal Control of Egg Activation That Influences Cortical Granule Exocytosis in Animal Species.Frontiers in cell and developmental biology · 2021Review
- A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.PLoS genetics · 2017Article
- Two pathways regulate cortical granule translocation to prevent polyspermy in mouse oocytes.Nature communications · 2016Article
- Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs.Experimental cell research · 2016Article
- Involvement of Rab6a in organelle rearrangement and cytoskeletal organization during mouse oocyte maturation.Scientific reports · 2016Article
- The biology and dynamics of mammalian cortical granules.Reproductive biology and endocrinology : RB&E · 2011Review
- Secretory mechanisms and Ca2+ signaling in gametes: similarities to regulated neuroendocrine secretion in somatic cells and involvement in emerging pathologies.Endocrine pathology · 2007Review
- Biochemical heterogeneity, migration, and pre-fertilization release of mouse oocyte cortical granules.Reproductive biology and endocrinology : RB&E · 2003Article
- Physiological modulation of rabphilin phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Developmental regulation and specific brain distribution of phosphorabphilin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Sorting and storage during secretory granule biogenesis: looking backward and looking forward.The Biochemical journal · 1998Review
- Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic.The Journal of general physiology · 1998Article
- Effect of KN-62, a selective inhibitor of calmodulin-dependent kinase II, on mouse oocyte activation.Journal of assisted reproduction and genetics · 1997Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rabphilin-3A is a putative target protein for Rab3A, a member of the small GTP-binding protein superfamily that has been suggested to play a role in regulated exocytosis in presynapses. In this study we determined the expression and the function of Rabphilin-3A in mouse eggs at fertilization. Rabphilin-3A mRNA and protein were detected by reverse transcriptase-PCR and immunoblot analysis, respectively, in metaphase II mouse eggs. Immunofluorescence analysis showed that Rabphilin-3A protein was distributed in the cortical region in eggs. Sperm induces cortical granule (CG) exocytosis via an increase in cytosolic Ca2+ at fertilization. We microinjected the NH2- or COOH-terminal fragment of recombinant Rabphilin-3A into metaphase II eggs. Neither treatments altered the sperm-induced cytosolic Ca2+ increase, but both inhibited CG exocytosis in a dose-dependent manner. The NH2-terminal fragment was more effective than the COOH-terminal fragment. Full-length Rabphilin-3A did not affect CG exocytosis, but it attenuated the inhibition of CG exocytosis by the NH2-terminal fragment. These results show that Rabphilin-3A is involved in Ca(2+)-dependent CG exocytosis at fertilization in mouse eggs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.