ArticleRNA (New York, N.Y.)1997
Identification of specific nucleotide sequences and structural elements required for intronic U14 snoRNA processing.
Article in RNA (New York, N.Y.), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 62 citations in OpenAlex.
- Computational limitations and future needs to unravel the full potential of 2'-O-methylation and C/D box snoRNAs.RNA biology · 2025Review
- SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.Nucleic acids research · 2025Article
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- Motif conservation, stability, and host gene expression are the main drivers of snoRNA expression across vertebrates.Genome research · 2023Article
- The fungal snoRNAome.RNA (New York, N.Y.) · 2018Article
- SnoReport 2.0: new features and a refined Support Vector Machine to improve snoRNA identification.BMC bioinformatics · 2016Article
- Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing.The EMBO journal · 2011Article
- Structural features of the guide:target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2'-O-methylation.RNA (New York, N.Y.) · 2007Article
- Genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Leishmania major indicates conservation among trypanosomatids in the repertoire and in their rRNA targets.Eukaryotic cell · 2007Article
- Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner.Molecular and cellular biology · 2006Article
- Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein.RNA (New York, N.Y.) · 2005Article
- A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification.RNA (New York, N.Y.) · 2005Article
- Conserved spacing between the box C/D and C'/D' RNPs of the archaeal box C/D sRNP complex is required for efficient 2'-O-methylation of target RNAs.RNA (New York, N.Y.) · 2005Article
- Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.Molecular and cellular biology · 2002Article
- Archaeal ribosomal protein L7 is a functional homolog of the eukaryotic 15.5kD/Snu13p snoRNP core protein.Nucleic acids research · 2002Article
- The 3' end formation in small RNAs.Gene expression · 2002Review
- Release of U18 snoRNA from its host intron requires interaction of Nop1p with the Rnt1p endonuclease.The EMBO journal · 2001Article
- Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- An unexpected, conserved element of the U3 snoRNA is required for Mpp10p association.RNA (New York, N.Y.) · 2001Article
- Processing of intron-encoded box C/D small nucleolar RNAs lacking a 5',3'-terminal stem structure.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate U14 snoRNAs are encoded within hsc70 pre-mRNA introns and U14 biosynthesis occurs via an intron-processing pathway. We have shown previously that essential processing signals are located in the termini of the mature U14 molecule and replacement of included boxes C or D with oligo C disrupts snoRNA synthesis. The experiments detailed here now define the specific nucleotide sequences and structures of the U14 termini that are essential for intronic snoRNA processing. Mutagenesis studies demonstrated that a 5', 3'-terminal stem of at least three contiguous base pairs is required. A specific helix sequence is not necessary and this stem may be extended to as many as 15 base pairs without affecting U14 processing. The spatial positioning of boxes C and D with respect to the terminal stem is also important. Detailed analysis of boxes C and D revealed that both consensus sequences possess essential nucleotides. Some, but not all, of these critical nucleotides correspond to those required for the stable accumulation of nonintronic yeast U14 snoRNA. The presence of box C and D consensus sequences flanking a terminal stem in many snoRNA species indicates the importance of this "terminal core motif" for snoRNA processing.
Indexed as
Identifiers
8990395PMC1369458W2111348055What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.