ArticleProceedings of the National Academy of Sciences of the United States of America1997
The choroid plexus epithelium is the site of the organic anion transport protein in the brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 140 citations in OpenAlex.
- The Biosynthesis, Signaling, and Neurological Functions of Bile Acids.Biomolecules · 2019Review
- SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers.The AAPS journal · 2017Review
- Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.The AAPS journal · 2017Review
- Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury.Scientific reports · 2017Article
- Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System.Frontiers in neuroscience · 2017Review
- Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS.Pflugers Archiv : European journal of physiology · 2015Article
- Drug transporters in the central nervous system.Clinical pharmacokinetics · 2015Review
- Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?Current pharmaceutical design · 2014Review
- Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Vectorial ligand transport through mammalian choroid plexus.Pharmaceutical research · 2010Review
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Thyroid hormone transporters in the brain.Cerebellum (London, England) · 2008Review
- Rat organic anion transporting protein 1A1 (Oatp1a1): purification and phosphopeptide assignment.Biochemistry · 2006Article
- The role of P-glycoprotein and organic anion-transporting polypeptides in drug interactions.Drug safety · 2005Review
- Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus.Pharmaceutical research · 2003Article
- The impact of efflux transporters in the brain on the development of drugs for CNS disorders.Clinical pharmacokinetics · 2002Review
- Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.Clinical pharmacokinetics · 2002Review
- Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models.Pharmaceutical research · 2001Article
- Hepatocellular transport proteins and their role in liver disease.World journal of gastroenterology · 2001Review
- Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.The Journal of clinical investigation · 2000Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The mRNA for organic anion transport protein (oatp) was previously shown to be present in abundance in liver and kidney, and in small amounts in brain. Data obtained from experiments with reverse transcriptase-PCR techniques and in situ hybridization analysis showed that the oatp mRNA is present within the brain, localized to the choroid plexus. A sequence-specific antibody to the oatp polypeptide demonstrated the presence of the expected polypeptide with a molecular weight of 80,000 plus an immunoreactive species with a higher molecular weight in preparations of choroid plexus membranes. Examination of the choroid plexus by fluorescence confocal microscopy revealed that immunoreactive oatp polypeptide is localized to the apical surface of the choroid plexus epithelial cells, which contacts the cerebrospinal fluid. This localization of oatp is consistent with previous experiments showing vectorial transport of organic anions between the choroid plexus and the cerebrospinal fluid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.