ArticleProceedings of the National Academy of Sciences of the United States of America1997
Memory B lymphocytes migrate to bone marrow in humans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 137 citations in OpenAlex.
- HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.The Journal of experimental medicine · 1998Trial
- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- Bone: A Neglected Endocrine Organ?Journal of clinical medicine · 2024Review
- Shigella virulence protein VirG is a broadly protective antigen and vaccine candidate.NPJ vaccines · 2024Article
- Circulating lymphocyte trafficking to the bone marrow contributes to lymphopenia in myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2022Article
- Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival.The Journal of experimental medicine · 2021Article
- Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.Frontiers in immunology · 2021Review
- Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.Nature communications · 2020Article
- Deep Characterization of the Human Antibody Response to Natural Infection Using Longitudinal Immune Repertoire Sequencing.Molecular & cellular proteomics : MCP · 2020Article
- Review
- Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination.Frontiers in immunology · 2019Review
- Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection.Science advances · 2018Article
- Immunological memories of the bone marrow.Immunological reviews · 2018Review
- Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire.Nature communications · 2016Observational
- Vaccination to gain humoral immune memory.Clinical & translational immunology · 2016Review
- Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation.Viral immunology · 2016Article
- B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Distribution of CD10-positive epithelial and mesenchymal cells in human mid-term fetuses: a comparison with CD34 expression.Anatomy & cell biology · 2014Article
- Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models.ISRN hematology · 2013Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
IgM-bearing B lymphocytes with mature phenotype (CD10- CD24(lo) IgD+) are acquired after birth in the bone marrow of humans. These B cells are defined here as relatively large, nondividing lymphocytes, variable proportions of which express cell surface molecules indicative of relatively recent activation. Analysis of V(H)5(2) (heavy chain variable region) gene transcripts indicated point mutations throughout the Ig variable region from the mature IgM+ B population but not from the immature B cells in the bone marrow. The mutations were concentrated in the complementarity determining regions, and amino acid substitutions were favored over silent mutations, findings indicative of antigen selection within germinal centers in peripheral lymphoid tissues. The V(H) sequence analysis also revealed the existence of clonal relatives in individual bone marrow samples. These antigen-experienced lymphocytes did not secrete Ig spontaneously but could be induced to do so in vitro. The data suggest that a subpopulation of memory B lymphocytes generated during antigen responses recirculates to the bone marrow in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.