ArticleThe Plant cell1996
Protein farnesyltransferase in plants: molecular characterization and involvement in cell cycle control.
Article in The Plant cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond.Frontiers in pharmacology · 2026Review
- Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana.BMC plant biology · 2010Article
- The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypes.BMC plant biology · 2010Article
- The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells.The Plant cell · 2009Article
- Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus.Plant cell reports · 2009Article
- Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis.The Plant cell · 2008Article
- Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis.Plant physiology · 2008Article
- Developmentally controlled farnesylation modulates AtNAP1;1 function in cell proliferation and cell expansion during Arabidopsis leaf development.Plant physiology · 2006Article
- Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbifera: in planta production and implications for competitive fitness.Journal of chemical ecology · 2005Article
- Protein geranylgeranyltransferase I is involved in specific aspects of abscisic acid and auxin signaling in Arabidopsis.Plant physiology · 2005Article
- CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.Plant molecular biology · 2005Article
- The Use of Arabidopsis to Study Interactions between Parasitic Angiosperms and Their Plant Hosts.The arabidopsis book · 2002Article
- Heterotrimeric and unconventional GTP binding proteins in plant cell signaling.The Plant cell · 2002Review
- The Rop GTPase switch controls multiple developmental processes in Arabidopsis.Plant physiology · 2001Article
- Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells.Plant physiology · 2000Article
- Functional requirement of plant farnesyltransferase during development in Arabidopsis.The Plant cell · 2000Article
- Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein.The EMBO journal · 1999Article
- Prenylcysteine alpha-carboxyl methyltransferase in suspension-cultured tobacco cellsPlant physiology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Farnesylation is required for membrane targeting, protein-protein interactions, and the biological activity of key regulatory proteins, such as Ras small GTPases and protein kinases in a wide range of eukaryotes. In this report, we describe the molecular identification of a plant protein farnesyltransferase (FTase) and evidence for its role in the control of the cell cycle in plants. A pea gene encoding a homolog of the FTase beta subunit was previously cloned using a polymerase chain reaction-based strategy. A similar approach was used to clone a pea gene encoding a homolog of the FTase alpha subunit. The biochemical function of the pea FTase homologs was demonstrated by the reconstitution of FTase enzyme activity using FTase fusion proteins coexpressed in Escherichia coll. RNA gel blot analyses showed that levels of FTase mRNAs are generally higher in tissues, such as those of nodules, that are active in cell division. The relationship of FTase to cell division was further analyzed during the growth of suspension-cultured tobacco BY-2 cells. A biphasic fluctuation of FTase enzyme activity preceded corresponding changes in mitotic activity at the early log phase of cell growth. Moreover, manumycin, a specific inhibitor of FTase, was effective in inhibiting mitosis and growth in these cells. Using synchronized BY-2 cells, manumycin completely blocked mitosis when added at the early S phase but not when added at the G2 phase. These data suggest that FTase is required for the plant cell cycle, perhaps by modulating the progression through the S phase and the transition from G1 to the S phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.