ArticleThe Plant cell1996
Interactions across exons can influence splice site recognition in plant nuclei.
Article in The Plant cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Rare occurrence of cryptic 5' splice sites by downstream 3' splice site/exon boundary mutations in a heavy-ion-inducedFrontiers in plant science · 2024Article
- Genome Engineering and Agriculture: Opportunities and Challenges.Progress in molecular biology and translational science · 2017Review
- Cross-kingdom patterns of alternative splicing and splice recognition.Genome biology · 2008Article
- Coevolutionary networks of splicing cis-regulatory elements.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Analysis of splice donor and acceptor function in a novel Ac-based gene trap construct.Planta · 2004Article
- Determinants of plant U12-dependent intron splicing efficiency.The Plant cell · 2004Article
- A splice site mutant of maize activates cryptic splice sites, elicits intron inclusion and exon exclusion, and permits branch point elucidation.Plant physiology · 1999Article
- The AG dinucleotide terminating introns is important but not always required for pre-mRNA splicing in the maize endospermPlant physiology · 1999Article
- An intragenic suppressor of the Arabidopsis floral organ identity mutant apetala3-1 functions by suppressing defects in splicing.The Plant cell · 1998Article
- Temperature-sensitive splicing in the floral homeotic mutant apetala3-1.The Plant cell · 1998Article
- G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In vivo analyses of cis-acting sequence requirements for pre-mRNA splicing in tobacco nuclei have previously demonstrated that the 5' splice sites are selected by their position relative to AU-rich elements within plant introns and by their degree of complementarity to the U1 small nuclear RNA. To determine whether the presence of adjacent introns affects 5' splice site recognition in plant nuclei, we have analyzed the in vivo splicing patterns of two-intron constructs containing 5' splice site mutations in the second intron. These experiments indicated that the splice site selection patterns in plant nuclei are defined primarily by sequences within the intron (intron definition) and secondarily by weak interactions across exons (exon definition). The effects of these secondary interactions became evident only when mutations in the downstream 5' splice site decreased its functionality and differed depending on the availability of cryptic splice sites close to the mutant site. In beta-conglycinin chimeric transcripts containing multiple cryptic 5' splice sites, the presence of an intact upstream intron significantly increased splicing at the downstream 5' splice sites in a polar fashion without activating exon skipping. In a natural beta-conglycinin transcript, which does not contain cryptic 5'splice sites, mutation of the first nucleotide of the downstream intron activated an array of noncanonical 5' and 3' splice sites and some exon skipping.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.