Evidence map›Paper›PMID 8988899›Full record

ReviewThe New England journal of medicine1997

Melatonin in humans.

A Brzezinski

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in The New England journal of medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03848533 (Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes), which is not on this map. Cited by 388 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
388citing papers in PubMed, 12 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03848533 phase2unknown statusstarted 2019, after this paper: background citation

Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study

Ran2019Enrolled42Registered outcomes19Posted comparisons0ConditionsPrediabetesArmsMelatonin, Metformin, Placebo
PMID 27653034PMID 21241070PMID 17013468PMID 20701406PMID 7601013PMID 22722338PMID 17874238PMID 26059289PMID 29109369PMID 29222373PMID 31236502PMID 8529190other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

388 citing papers in PubMed, 12 syntheses or guidelines pooled it, 1,543 citations in OpenAlex.

  1. Melatonin treatment for neonatal encephalopathy.The Cochrane database of systematic reviews · 2026
    Pooled it
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  3. Pooled it
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  5. Melatonin for preoperative and postoperative anxiety in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  6. Pooled it
  7. Pooled it
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  9. Pooled it
  10. Pooled it
  11. Guideline
  12. Pooled it
  13. Trial
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  19. Effects of a violet-excitation light-emitting diode on melatonin secretion and sleepiness: preliminary findings from a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  20. Trial

328 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

A BrzezinskiDepartment of Obstetrics and Gynecology, Hebrew University Hadassah Medical School, Jerusalem, Israel.
Hebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingAnimalsCircadian RhythmFemaleHumansMaleMelatoninNeoplasmsPineal GlandPubertyReceptors, Cell SurfaceReproductionSleepMelatoninReceptors, Cell Surface

Identifiers

PMID8988899
OpenAlexW2323516874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.