ReviewExperientia1996
Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors.
Review in Experientia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.eLife · 2021Article
- Applying the Monod-Wyman-Changeux Allosteric Activation Model to Pseudo-Steady-State Responses from GABAMolecular pharmacology · 2019Review
- GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between ECMolecular pharmacology · 2018Article
- Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- An Update on GABAρ Receptors.Current neuropharmacology · 2010Article
- Mechanism of Allosteric Modulation of the Cys-loop Receptors.Pharmaceuticals (Basel, Switzerland) · 2010Review
- The role of Loop F in the activation of the GABA receptor.The Journal of physiology · 2010Review
- Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.Molecular neurobiology · 2009Review
- Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.British journal of pharmacology · 2009Article
- Allosteric activation mechanism of the cys-loop receptors.Acta pharmacologica Sinica · 2009Review
- Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor.European biophysics journal : EBJ · 2007Review
- Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.Biophysical journal · 2000Article
- Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.Biophysical journal · 1999Article
- Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key statement of the 1965 Monod-Wyman-Changeux (MWC) model for allosteric proteins concerns the distinction between the ligand-binding function (Y) and the relevant state function (R). Sequential models predict overlapping behavior of the two functions. In contrast, a straightforward experimental consequence of the MWC model is that for an oligomeric protein the parameters which characterize the two functions should differ significantly. Two situations, where R > Y and the system is hyper-responsive or where R < Y and the system is hypo-responsive, have been encountered. Indeed, the hyper-responsive pattern was first observed for the enzyme aspartate transcarbamoylase, by comparing Y with R monitored by a change in sedimentation. Extensions of the theory to ligand-gated channels led to the suggestion that, on the one hand, hyper-responsive properties also occur with high-affinity mutants. On the other hand, native channels of the acetylcholine neuronal alpha 7 receptor and low-affinity mutants of the glycine receptor can be interpreted in terms of the hypo-responsive pattern. For the ligand-gated channels, whereas R is detected directly by ion flux, ligand binding has rarely been measured and the formation of desensitized states may complicate the analysis. However, stochastic models incorporating both binding and channel opening for single molecules predict differences that should be measurable with new experimental approaches, particularly fluorescence correlation spectroscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.