ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Costorage and corelease of modulatory peptide cotransmitters with partially antagonistic actions on the accessory radula closer muscle of Aplysia californica.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 88 citations in OpenAlex.
- Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Distribution and Possible Roles of Small Cardioactive Peptide in the NudibranchIntegrative organismal biology (Oxford, England) · 2020Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- Peptide Cotransmitters as Dynamic, Intrinsic Modulators of Network Activity.Frontiers in neural circuits · 2018Review
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Release of a single neurotransmitter from an identified interneuron coherently affects motor output on multiple time scales.Journal of neurophysiology · 2013Article
- Collection of peptides released from single neurons with particle-embedded monolithic capillaries followed by detection with matrix-assisted laser desorption/ionization mass spectrometry.Analytical chemistry · 2011Article
- Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Composite modulatory feedforward loop contributes to the establishment of a network state.Journal of neurophysiology · 2010Article
- Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?Invertebrate neuroscience : IN · 2009Review
- Variability of motor neuron spike timing maintains and shapes contractions of the accessory radula closer muscle of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Peptidomics of a single identified neuron reveals diversity of multiple neuropeptides with convergent actions on cellular excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Temperature compensation of neuromuscular modulation in aplysia.Journal of neurophysiology · 2005Article
- Identification of a new neuropeptide precursor reveals a novel source of extrinsic modulation in the feeding system of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Concerted GABAergic actions of Aplysia feeding interneurons in motor program specification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Identification and characterization of the feeding circuit-activating peptides, a novel neuropeptide family of aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Many neurons that contain a classical neurotransmitter also contain modulatory peptides, but it has been difficult to establish unequivocally that these peptides are functional cotransmitters. Here, we provide evidence for functional cotransmission in a neuromuscular system of Aplysia. Using immunocytochemical techniques, we localize members of two peptide families, the small cardioactive peptides (SCPs) and the buccalins (BUCs), to a single subset of dense-core vesicles in the terminals of the cholinergic motorneuron B15. We describe a new preparation and method for the direct detection of released peptides and show that the SCPs and BUCs are released when neuron B15 is intracellularly stimulated. Consistent with their subcellular localization, the SCPs and BUCs are released in a stoichiometric ratio that is constant across conditions that change the absolute amount of peptides released. Peptide release is calcium-dependent but does not require muscle contractions. Thus, the release cannot be attributed to a displacement of peptides that may be present in the extracellular space. In previous studies, we characterized the physiological firing patterns of neuron B15. Here, we simulate these firing patterns and show that peptide release occurs. Additionally, we find that significant quantities of material are released under behaviorally relevant conditions. We find that concentrations of released peptides in the muscle are in the concentration range in which exogenously applied peptides exert characterized modulatory actions on muscle contractions. Together, our findings provide strong support for the hypothesis that peptides contained in neuron B15 are functional cotransmitters.
Indexed as
Identifiers
8987834PMC6579219W2153984957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.