ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
GABAergic presubicular projections to the medial entorhinal cortex of the rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- The entorhinal cortex of the monkey: VI. Organization of projections from the hippocampus, subiculum, presubiculum, and parasubiculum.The Journal of comparative neurology · 2021Article
- Functional neuroanatomy of the basolateral amygdala: Neurons, neurotransmitters, and circuits.Handbook of behavioral neuroscience · 2020Article
- Differences in functional connectivity along the anterior-posterior axis of human hippocampal subfields.NeuroImage · 2019Article
- Multiple Patterns of Axonal Collateralization of Single Layer III Neurons of the Rat Presubiculum.Frontiers in neural circuits · 2019Article
- Functional neuroanatomy of amygdalohippocampal interconnections and their role in learning and memory.Journal of neuroscience research · 2017Review
- Graph analysis of the anatomical network organization of the hippocampal formation and parahippocampal region in the rat.Brain structure & function · 2016Article
- Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy.Journal of neurophysiology · 2015Article
- Extrinsic origins of the somatostatin and neuropeptide Y innervation of the rat basolateral amygdala.Neuroscience · 2015Article
- GABAergic somatostatin-immunoreactive neurons in the amygdala project to the entorhinal cortex.Neuroscience · 2015Article
- Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum.Frontiers in neural circuits · 2015Article
- Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy.Journal of neurophysiology · 2014Article
- Architecture of spatial circuits in the hippocampal region.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Differential connectivity of short- vs. long-range extrinsic and intrinsic cortical inputs to perirhinal neurons.The Journal of comparative neurology · 2013Article
- All layers of medial entorhinal cortex receive presubicular and parasubicular inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A neuroanatomical model of prefrontal inhibitory modulation of memory retrieval.Neuroscience and biobehavioral reviews · 2012Review
- Vestibular and attractor network basis of the head direction cell signal in subcortical circuits.Frontiers in neural circuits · 2012Article
- The retrosplenial cortex: intrinsic connectivity and connections with the (para)hippocampal region in the rat. An interactive connectome.Frontiers in neuroinformatics · 2011Article
- Long-Range GABAergic Connections Distributed throughout the Neocortex and their Possible Function.Frontiers in neuroscience · 2010Article
- Structural organization of long-range GABAergic projection system of the hippocampus.Frontiers in neuroanatomy · 2009Article
- What does the anatomical organization of the entorhinal cortex tell us?Neural plasticity · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We characterized presubicular neurons giving rise to bilateral projections to the medial entorhinal cortex (MEA) of the rat. Retrograde labeling of presubiculo-entorhinal projections with horseradish peroxidase and subsequent GABA immunocytochemistry revealed that 20-30% of the ipsilaterally projecting neurons are GABAergic. No GABAergic projections to the contralateral MEA were observed. GABAergic projection neurons were observed only in the dorsal part of the presubiculum, which, when taking into account the topography of presubicular projections to MEA, indicates that only the dorsal part of MEA receives GABAergic input. The GABAergic projection neurons constitute approximately 30-40% of all GABAergic neurons present in the superficial layers of the dorsal presubiculum. Using double-label fluorescent retrograde tracing, we found that the ipsilateral and contralateral presubiculo-entorhinal projections originate from different populations of neurons. Anterograde labeling of presubiculo-entorhinal projections and electron microscopical analysis of labeled terminals substantiated the presence of a restricted GABAergic presubiculo-entorhinal projection. A small fraction of afferents to only ipsilateral dorsal MEA formed symmetrical synapses with dendritic shafts. No symmetrical synapses on spines were noted. Most afferents to the dorsal part of ipsilateral MEA, as well as all afferents to the remaining ipsilateral and contralateral MEA, formed asymmetrical synapses with both spines and dendritic shafts in an almost equal ratio. Thus, we conclude that the majority of the presubiculo-entorhinal projections exert an excitatory effect on both principal neurons and interneurons. The projections from the dorsal part of the presubiculum comprise a small inhibitory component that originates from GABAergic neurons and targets entorhinal interneurons.
Indexed as
Identifiers
8987807PMC6573230W2122638812What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.